急性脑梗死应用血管内介入联合通脑饮治疗的效果

Effect of intravascular intervention combined with tongnaoyin in the treatment of acute cerebral infarction

目的探讨急性脑梗死应用血管内介入联合通脑饮治疗的效果。方法选取荥阳市人民医院2017年6月至2021年6月收治的符合条件的86例ACI患者按随机数字表法划分成西医组(n=43)、中西医组(n=43)两组,西医组实施血管内介入治疗,中西医组在西医组基础上加用通脑饮。评定两组治疗2周后疗效及治疗3个月预后,比较两组治疗前后中医证候积分、美国国立卫生研究院卒中量表(NIHSS)评分、血清胰岛素样生长因子1(IGF-1)、神经元特异性烯醇化酶(NSE)水平。结果治疗2周后中西医组总有效率优于西医组,差异有统计学意义(χ^(2)=4.440,P<0.05)。治疗2周后两组中医证候积分、NIHSS评分均较治疗前降低,且治疗2周后中西医组均低于西医组,差异有统计学意义(P<0.05)。治疗2周后两组血清IGF-1水平均明显增高,血清NSE水平均明显降低,且治疗2周后中西医组血清IGF-1水平明显高于西医组,血清NSE水平明显低于西医组,差异有统计学意义(P均<0.05)。治疗3个月后,中西医组预后良好率高于西医组,差异有统计学意义(χ^(2)=4.715,P<0.05)。结论对ACI患者实施血管内介入联合通脑饮治疗的效果较佳,可明显减轻中医症状及神经功能损伤,有效调节血清IGF-1、NSE水平,显著改善预后。

Objective To investigate the effect of intravascular intervention combined with tongnaoyin in the treatment of acute cerebral infarction(ACI).Methods A total of 86 eligible ACI patients admitted to Xingyang People’s Hospital from June 2017 to June 2021 were selected and divided into two groups:Western medicine group(n=43)and Chinese and Western medicine group(n=43)according to the random number table method.In the Western medicine group,intravascular interventional therapy was performed,and in the TCM combined Western medicine group,Tongnao drink was added on the basis of the Western medicine group.The efficacy of the two groups was evaluated after 2 weeks of treatment and the prognosis of 3 months after treatment,the TCM syndrome score,National Institute of Health stroke scale(NIHSS)score,serum insulin-like growth factor 1(IGF-1)and neuron-specific enolase(NSE)levels were compared before and after treatment.Results After 2 weeks of treatment,the total effective rate of the Traditional Chinese and Western medicine group was better than that of the Western medicine group,and the difference was statistically significant(χ^(2)=4.440,P<0.05).After 2 weeks of treatment,TCM syndrome scores and NIHSS scores in the two groups were lower than those before treatment,and after 2 weeks of treatment,the TCM and Western medicine group were lower than those in the Western medicine group,and the difference was statistically significant(P<0.05).After 2 weeks of treatment,the levels of serum IGF-1 in the two groups were significantly increased,and the levels of serum NSE were significantly decreased.After 2 weeks of treatment,the level of serum IGF-1 in the Traditional Chinese and Western medicine group was significantly higher than that in the Western medicine group,and the serum NSE level was significantly lower than that in the Western medicine group.The differences were statistical significance(P<0.05).After 3 months of treatment,the good prognosis rate in the Chinese and Western medicine group was higher than that in the Western medicine group,and the difference was statistically significant(χ^(2)=4.715,P<0.05).Conclusion The effect of intravascular intervention combined with Tongnao Yin for ACI patients is better,which can significantly reduce the symptoms of Traditional Chinese medicine and nerve function damage,effectively regulate the serum IGF-1 and NSE levels,and significantly improve the prognosis.