血清miR-126、IGF-1水平与糖尿病前期人群结肠息肉发病的相关性

Correlation between serum miR-126 and IGF-1 levels and the incidence of colon polyps in prediabetic population

目的观察微小RNA-126(miR-126)、胰岛素样生长因子-1(IGF-1)与糖尿病(DM)前期发生人群结肠息肉发病的关系。方法选取2017年11月至2021年3月于广州中医药大学深圳医院治疗的DM前期人群673例,其中结肠息肉患者71例作为DM前期息肉组,结肠黏膜无病变者81例作为DM前期无息肉组,并根据息肉的临床特点以及病理结果将DM前期息肉组分为低危结肠息肉组和高危结肠息肉组;另选取同期糖耐量正常者140例作为对照组,其中结肠息肉29例作为正常息肉组,无结肠息肉111例作为正常无息肉组。检测受试者血清miR-126、IGF-1表达水平,分析两者相关性及对DM前期结肠息肉的诊断价值。结果血清miR-126、IGF-1表达水平比较:DM前期息肉组>DM前期无息肉组>正常息肉组>正常无息肉组,差异有统计学意义(P<0.05)。DM前期息肉组分为低危结肠息肉组(22例)和高危结肠息肉组(49例),高危结肠息肉组患者血清miR-126、IGF-1表达水平高于低危结肠息肉组,差异均有统计学意义(P<0.05)。DM前期结肠息肉患者血清中miR-126与IGF-1表达水平呈正相关(r=0.447,P<0.05)。血清miR-126联合IGF-1诊断DM前期结肠息肉的曲线下面积明显高于两者单独诊断(P<0.05)。结论miR-126、IGF-1在DM前期结肠息肉血清中高表达,均可作为诊断结肠息肉的指标。

Objective To observe the relationship between microRNA-126(miR-126)and insulinlike growth factor-1(IGF-1)and the incidence of colonic polyps in prediabetes mellitus(DM)population.Methods A total of 673 patients with pre-DM treated in Shenzhen Hospital Guangzhou University of Traditional Chinese Medicine from November 2017 to March 2021 were selected,including 71 patients with colonic polyps as the pre DM polyp group and 81 patients without lesions of colonic mucosa as the pre-DM polyp free group,according to the clinical characteristics and pathological results of polyps,the pre DM polyps were divided into low-risk colonic polyps group(22 cases)and high-risk colonic polyps group(49 cases).Another 140 cases with normal glucose tolerance in the same period were selected as the control group,including 29 cases of colonic polyps as the normal polyp group and 111 cases without colonic polyps as the normal polyp free group.The expression levels of serum miR-126 and IGF-1 were detected,and the correlation between them was analyzed,as well as the diagnostic value of colonic polyps in pre-DM.Results Comparison of serum miR-126and IGF-1 expression levels:pre-DM polyp group>pre-DM polyp free group>normal polyp group>normal polyp free group,the difference was statistically significant(P<0.05).The expression levels of serum miR-126 and IGF-1 in high-risk colonic polyps group were significantly higher than those in low-risk colonic polyps group,the difference was statistically significant(P<0.05).The expression levels of miR-126 and IGF-1 in serum of patients with colonic polyps in pre-DM were positively correlated(r=0.447,P<0.05).The area under the curve of serum miR-126 combined with IGF-1 in the diagnosis of pre-DM colonic polyps was significantly higher than that of both alone(P<0.05).Conclusions MiR-126 and IGF-1 are highly expressed in the serum of colonic polyps in the pre-DM stage,which can be used as indicators for the diagnosis of colonic polyps.