头孢哌酮钠舒巴坦钠用药前后国际标准化比值相关分析

Correlation Analysis of International Normalized Ratio before and after Administration of Cefoperazone Sodium-sulbactam Sodium

目的:探讨头孢哌酮钠舒巴坦钠用药前后国际标准化比值相关分析。方法:纳入安徽省阜阳市阜南县中医院于2020年8月~2021年10月收治的12例用头孢哌酮钠-舒巴坦钠治疗的患者,观察国际标准化比值(INR)、凝血酶原时间(PT)、血小板计数(PLT)以及活化部分凝血活酶时间(APTT)的用药前后变化情况。并分析患者年龄、性别、肾功能、慢性健康状况评分Ⅱ(APACHEⅡ)与急性生理学、头孢哌酮钠-舒巴坦钠日疗程、剂量与凝血功能异常的相关性。结果:12例受试者中凝血功能异常2(16.66%);用药后INR、PT、APTT均较用药前延长(P<0.05),PLT无明显变化(P>0.05);停药/给予维生素K1其凝血功能均能恢复;正常组APACHEⅡ评分低于异常组(P<0.05)。结论:头孢哌酮钠-舒巴坦钠可对部分患者特别是危重患者的凝血功能造成影响,延长其国际标准化比值(INR)。

Objective:To investigate the correlation analysis of international normalized ratio before and after administration of cefoperazone sodium and sulbactam sodium.Methods:A total of 12 patients treated with cefoperazone sodium-sulbactam sodium in Funan County Traditional Chinese Medicine Hospital from August 2020 to October 2021 were included.The changes of international normalized ratio(INR),prothrombin time(PT),platelet count(PLT)and activated partial thromboplastin time(APTT)before and after administration of cefoperazone sodium and sulbactam sodium were observed.The correlation between age,gender,renal function,chronic health status scoreⅡ(APACHEⅡ)and acute physiology,daily course of cefoperazone sodium-sulbactam sodium,dose and abnormal coagulation function were analyzed.Results:2(16.66%)of 12 subjects had abnormal coagulation function;INR,PT and APTT were prolonged after treatment(P<0.05),and PLT had no significant change(P>0.05);with drug withdrawal/vitamin administration,the coagulation function of K1 could be recovered;the APACHEⅡscore of the normal group was lower than that of the abnormal group(P<0.05).Conclusion:Cefoperazone sodium-sulbactam sodium can affect the coagulation function of some patients,especially critically ill patients,and prolong the international normalized ratio(INR).