小六金健胃方治疗慢性浅表性胃炎中虚气滞型临床观察

Clinical Observation of Xiaoliujin Jianwei Decoction in the Treatment of Chronic Superficial Gastritis with Qi Stagnation Type

目的:观察小六金健胃方治疗慢性浅表性胃炎中虚气滞型的效果。方法:70例随机分为两组各35例,雷贝拉唑组用雷贝拉唑,小六金健胃方组用小六金健胃方。结果:胃镜疗效两组比较差异无统计学意义(P>0.05)。中医证候疗效小六金健胃方组优于雷贝拉唑组(P<0.05)。中医证候评分小六金健胃方组低于雷贝拉唑组(P<0.05)。治疗后小六金健胃方组胃蛋白酶原Ⅰ、胃泌素-17高于雷贝拉唑组(P<0.05)。两组治疗后肿瘤坏死因子-α、白介素-6均降低(P<0.05),治疗后两组肿瘤坏死因子-α、白介素-6比较差异无统计学意义(P>0.05)。两组不良反应比较差异无统计学意义(P>0.05)。结论:小六金健胃方治疗慢性浅表性胃炎中虚气滞型疗效较好。

Objective:To observe the effect of Xiaoliujin Jianwei Prescription on chronic superficial gastritis with middle-jiao deficiency and qi stagnation.Methods:Seventy cases were randomly divided into two groups,with 35 cases in each group.The rabeprazole group were given rabeprazole,while the Xiaoliujin Jianwei Prescription group were given Xiaoliujin Jianwei Prescription.Results:There was no significant difference in the efficacy of gastroscopy between the two groups(P>0.05).The efficacy of TCM syndromes in Xiaoliujin Jianwei Prescription group was better than that in rabeprazole group(P<0.05).The TCM syndrome score of Xiaoliujin Jianwei Prescription group was lower than that of rabeprazole group(P<0.05).After treatment,the levels of pepsinogen I and gastrin-17 in Xiaoliujin Jianwei Prescription group were higher than those in rabeprazole group(P<0.05).After treatment,tumor necrosis factor-αand interleukin-6 in the two groups were decreased(P<0.05),and there was no significant difference in tumor necrosis factor-αand interleukin-6 between the two groups after treatment(P>0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:Xiaoliujin Jianwei Prescription has good curative effect in treating chronic superficial gastritis with middle-jiao deficiency and qi stagnation type.