红参-胶原蛋白肽复配饮品对小鼠造血能力和免疫调节功能的影响

Effects of a Red Ginseng and Donkey-Hide Gelatin Composite Beverage on Hematopoietic Ability and Immunomodulatory Function in Mice

该研究以红参、阿胶肽为主要功能原料,添加胶原蛋白肽、酵母β葡聚糖、N-乙酰神经氨酸、鸡肉蛋白肽、桂圆粉、红枣粉、γ-氨基丁酸等辅料,根据国家固体饮料标准,进行复配,开发了一款复合功能饮品。应用试剂盒体外检测饮料的抗氧化作用,构建气血双虚小鼠模型检测饮品对小鼠免疫功能的影响。研究结果表明,自制研发的固体饮料在100mg/mL浓度下,总抗氧化能力可达0.25U/mL。此外,它使气血双虚模型小鼠的白细胞、淋巴细胞、血小板的数目得到了恢复,可明显改善脾脏损害,降低MDA的含量及增强小鼠抗氧化酶SOD、GSH-Px的活性,减少氧化损伤。该饮品具有一定的抗氧化能力,改善造血系统及增强免疫力的作用,有望开发成为一款多功能的食品投入市场。

Red ginseng and donkey-hide gelatin peptide were used as the main functional raw materials to develop a functional composite beverage, into which auxiliary materials were added, including collagen peptide, yeast β-glucan, N-acetylneuraminic acid, chicken peptide,longan powder, red date powder, and γ-aminobutyric acid, according to the National Solid Beverage Standards. The antioxidant effects of the beverage were detected in vitro, and a mouse model of Qi and blood deficiency was constructed to determine the effect of the beverage on immune function. The results show that the total antioxidant capacity of the beverage at 100 mg/mL was 0.25 U/mL. In addition, the beverage restored the number of leukocytes, lymphocytes, and platelets in mice with Qi and blood deficiency. The beverage also significantly alleviated spleen damage, reduced MDA contents, and enhanced the activities of antioxidant enzymes(superoxide dismutase and glutathione peroxidase),thereby reducing oxidative damage. Furthermore, the beverage could significantly improve antioxidant capacity, hematopoietic ability, and immunomodulatory function in mice. Overall, the functional beverage had abundant beneficial effects and shows promise as a marketable multifunctional food in the future.