ICU危重症患者随机血糖与细胞免疫指标的相关性分析

Correlation between random blood glucose and cellular immune indexes in critically ill patients in ICU

目的探讨重症监护室(ICU)危重症患者随机血糖与细胞免疫指标的相关性。方法选取联勤保障部队第904医院2020年9月—2021年9月收治的80例危重症患者为研究对象,设为观察组,另选取本院同期体检健康的80名志愿者为研究对象,设为对照组。比较两组的随机血糖水平、细胞免疫指标,将观察组患者根据不同随机血糖水平分为正常组、偏高组、高血糖组,比较不同随机血糖水平患者的细胞免疫指标,对随机血糖水平与细胞免疫指标的相关性进行分析,以皮尔森相关系数(Pearson)检验。结果观察组随机血糖水平显著高于对照组,白细胞分化簇3(CD3^(+))、白细胞分化簇4(CD4^(+))水平显著低于对照组,差异有统计学意义(P<0.05);观察组CD3^(+)、CD4^(+)、白细胞分化簇8(CD8^(+))水平比较,正常组>偏高组>高血糖组,差异有统计学意义(P<0.05)。经相关性分析,CD3^(+)、CD4^(+)、CD8^(+)水平与随机血糖水平呈负相关,均有P<0.05。结论ICU危重症患者的随机血糖水平及细胞免疫指标均与健康者有显著差异,且重症患者的随机血糖水平与细胞免疫指标CD3^(+)、CD4^(+)、CD8^(+)水平呈负相关。

Objective To investigate the relationship between random blood glucose and cellular immunity in critically ill patients with critically severe diseases or injury in ICU.Methods 80 critically ill patients treated in 904 Hospital of joint logistics support force from September 2020 to September 2021 were selected as the research object and set as the observation group,In addition,80 healthy volunteers in our hospital were selected as the research object and set as the control group.The random blood glucose levels and cellular immune indexes of the two groups were compared.The patients in the observation group were divided into normal group,high blood glucose group and high blood glucose group according to different random blood glucose levels.The cellular immune indexes of patients with different random blood glucose levels were compared.The correlation between random blood glucose levels and cellular immune indexes was analyzed and tested by Pearson coefficient.Results The random blood glucose level of the observation group was significantly higher than that of the control group,and the levels of CD3^(+)and CD4^(+)were significantly lower than those of the control group(all P<0.05).In the observation group,the levels of CD3^(+),CD4^(+)and CD8^(+)of the normal blood sugar subgroup was the highest,and the levels of CD3^(+),CD4^(+)and CD8^(+)of the on-the-high-side subgroup were significantly higher than those of the hyperglycemia subgroup(all P<0.05).Correlation analysis showed that CD3^(+),CD4^(+),and CD8^(+)levels were negatively correlated with random blood glucose level(all P<0.05).Conclusion The random blood glucose level of the critically ill patients is significantly higher that that of the normal people,and the cellular immune indexes of the critically ill patients in ICU are significantly lower than those of healthy subjects.The random blood glucose levels of critically ill patients are negatively correlated with the cellular immune indexes.