胸腔镜肺大疱切除术在肺气肿患者中的临床效果及对肺功能和炎症因子的影响

Clinical Effect of Thoracoscopic Bullectomy in Patients with Emphysema and Its Effect on Lung Function and Inflammatory Factors

目的:探讨胸腔镜肺大疱切除术在肺气肿患者中的临床效果及对肺功能和炎症因子的影响。方法:从2020年2月-2021年2月在黄冈市中心医院进行治疗的肺气肿患者中抽选84例患者为研究对象,借助随机数字法将患者分为两组,对照组应用常规手术治疗,研究组应用胸腔镜肺大疱切除术治疗。对两组患者的临床指标(手术时间、术后漏气时间、术后应用镇痛剂的时间、住院天数、手术费用)、肺功能[第1秒用力呼气量(FEV_(1))、用力肺活量(FVC)、FEV_(1)/FVC、呼气流量峰值(PEF)]及炎症因子水平[肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-18(IL-18)、超敏C反应蛋白(hs-CRP)]进行比较。结果:与对照组相比,研究组手术时间、术后漏气时间、术后应用镇痛剂的时间、住院天数短,且研究组手术费用少(P<0.05);与对照组相比,研究组治疗后FEV_(1)、FVC、PEF、FEV_(1)/FVC水平高(P<0.05);与对照组相比,研究组治疗后TNF-α、IL-6、IL-18、hs-CRP水平低(P<0.05)。结论:在肺气肿患者进行临床治疗中,应用胸腔镜肺大疱切除术治疗,具有确切的临床效果,可有效优化临床指标,改善肺功能,同时,有效降低炎症因子含量,抑制炎症反应,有利于增强预后,值得推广。

Objective:To investigate the clinical effect of thoracoscopic bullectomy in patients with emphysema and the effect on lung function and inflammatory factors.Method:A total of 84 patients with emphysema who were treated in Huanggang Central Hospital from February 2020 to February 2021 were selected as the subjects of the study.The patients were divided into two groups by means of random number method.The control group was treated with conventional surgery,and the study group was treated with thoracoscopic bullectomy.Clinical indicators(operation time,postoperative air leakage time,postoperative analgesic application time,length of hospital stay,surgical cost),lung function such as forced expiratory volume in 1 second(FEV_(1)),forced vital capacity(FVC),FEV_(1)/FVC,peak expiratory flow(PEF),and inflammatory factors such as tumor necrosis factor(TNF-α),interleukin-6(IL-6),interleukin-18(IL-18),hypersensitive C-reactive protein(hs-CRP)in two groups were compared.Result:Compared with the control group,the operative time,postoperative air leakage time,postoperative analgesic application time,hospitalization days were shorter and the operative cost were less in the study group(P<0.05).Compared with the control group,the levels of FEV_(1),FVC,PEF and FEV_(1)/FVC in the study group were higher after treatment(P<0.05).Compared with the control group,the levels of TNF-α,IL-6,IL-18 and hs-CRP in the study group were lower after treatment(P<0.05).Conclusion:In the clinical treatment of emphysema patients,the application of thoracoscopic pulmonary bullectomy has a specific clinical effect,can effectively optimize the clinical indicators,improve lung function,at the same time,effectively reduce the content of inflammatory factors,inhibit inflammatory reaction,is conducive to enhance the prognosis,worthy of promotion.