早期肠内营养与延迟肠内营养治疗重症急性胰腺炎的临床效果比较

Comparative of Clinical Effects of Early Enteral Nutrition and Delayed Enteral Nutrition in the Treatment of Severe Acute Pancreatitis

目的:探讨早期肠内营养与延迟肠内营养治疗重症急性胰腺炎的临床效果。方法:采用随机数字表分组法将2020年4月-2021年4月于武汉市新洲区红十字会医院接受治疗的70例重症急性胰腺炎患者分别纳入对照组和观察组,各35例。两组均统一接受常规治疗干预;在此基础上,对照组开展延迟肠内营养治疗,观察组开展早期肠内营养治疗。对比两组临床相关指标、炎症因子指标和并发症发生率。结果:观察组腹痛、腹胀消失时间,肠鸣音、排泄功能恢复时间及住院时长均明显优于对照组(P<0.05)。干预后,两组各项炎症因子水平均低于干预前,且观察组C反应蛋白、降钙素原、白细胞介素-6及肿瘤坏死因子-α(TNF-α)水平均低于对照组(P<0.05)。干预后,观察组各项并发症发生率均明显低于对照组(P<0.05)。结论:与延迟肠内营养治疗相比,应用早期肠内营养方法治疗重症急性胰腺炎的临床效果更为显著,可明显加快患者的预后康复速度,减少机体炎症表现,降低并发症发生率,值得进行推广应用。

Objective:To explore the clinical effect of early enteral nutrition and delayed enteral nutrition in the treatment of severe acute pancreatitis.Method:A total of 70 patients of severe acute pancreatitis treated in Wuhan Xinzhou District Red Cross Hospital from April 2020 to April 2021 were divided into control group and observation group by random number table grouping method,with 35 cases in each group.Both groups received routine treatment intervention.On this basis,delayed enteral nutrition was performed in the control group and early enteral nutrition was performed in the observation group.The clinical related indexes,inflammatory factors and the incidence of complications were compared between the two groups.Result:The disappearance time of abdominal pain,abdominal distention,recovery time of bowel sounds and excretory function and length of hospital stay in the observation group were significantly better than those in the control group(P<0.05).After the intervention,the levels of inflammatory factors in the two groups were lower than those before the intervention,and the levels of C-reactive protein,procalcitonin,interleukin-6 and tumor necrosis factor-α(TNF-α)in the observation group were lower than those in the control group(P<0.05).After the intervention,the incidences of complications in the observation group were significantly lower than those in the control group(P<0.05).Conclusion:Compared with delayed enteral nutrition,the clinical effect of early enteral nutrition in the treatment of severe acute pancreatitis is more significant.It can significantly accelerate the prognosis and rehabilitation of patients,reduce the performance of inflammation and reduce the incidence of complications.It is worthy of popularization and application.