腺性膀胱炎患者经尿道病损电切术后复发的危险因素

Risk factors of recurrence after transurethral resection in patients with cystitis glandularis

目的探讨腺性膀胱炎(CG)患者经尿道病损电切术(TUR)后复发的独立危险因素。方法回顾性分析2011年1月-2020年12月西京医院泌尿外科230例行TUR术CG患者的临床病理资料,所有患者术后规律来院随访。使用单因素及多因素logistic回归分析探索影响术后复发的危险因素。结果本组53例患者(23.0%)术后复发,中位复发时间6(1~36)个月,平均7.1个月。多因素logistic回归分析结果显示,年龄(P=0.001)、合并盆腔脂肪增多症(PL)(P<0.001)、肠化生型CG(P=0.008)、膀胱镜下形态(P=0.024)以及中性粒细胞绝对值/淋巴细胞绝对值(NLR)(P<0.001)是术后复发的独立危险因素。结论年龄、合并PL、病理类型、膀胱镜下形态以及术前NLR是CG患者TUR术后复发的独立危险因素,而膀胱化疗药物灌注并不能使患者显著获益。

Objective To investigate the independent risk factors of recurrence after transurethral resection(TUR)in patients with cystitis glandularis(CG).Methods A retrospective analysis was conducted on the clinicopathological data of 230 patients who underwent TUR at Xijing Hospital during Jan.2011 and Dec.2020.All cases were followed up regularly.The independent risk factors affecting recurrence after surgery were assessed with univariable and multivariable logistic regression analyses.Results Recurrence occurred in 53 patients(23.0%),with a median time to recurrence of 6(1 to 36)months(mean 7.1 months).On multivariable analyses,age(P=0.001),pelvic lipomatosis(PL)(P<0.001),intestinal metaplasia type of CG(P=0.008),cystoscopic morphology of the mucosa(P=0.024)and the neutrophil to lymphocyte ratio(NLR)(P<0.001)were the independent risk factors of recurrence after surgery.Conclusion Age,pelvic lipomatosis,intestinal metaplasia type of CG,cystoscopic morphology of the mucosa and preoperative NLR are identified as independent risk factors of recurrence following TUR,whereas patients can not significantly benefit from intravesical chemotherapeutic agents.