肿瘤分期和盆腔外放疗剂量是放疗后输尿管狭窄的独立危险因素

Tumor stage and pelvic radiotherapy dose are independent risk factors for ureteral stenosis after radiotherapy

目的分析宫颈癌放疗后输尿管狭窄的因素并对其处理方式进行讨论。方法收集2013年1月1日-2018年6月31日在新疆医科大学第一附属医院行放射性治疗的163例宫颈癌患者资料,对年龄、肿瘤分期(FIGO分期)、是否同步化疗、盆腔外放疗剂量、术前血红蛋白等14个相关因素进行单因素、多因素Cox回归分析。结果本组163例患者中,出现输尿管狭窄患者共20例(8.15%),其中左侧3例,右侧8例,双侧9例。狭窄出现时间平均在782.85(37~2323)d。单因素及多因素Cox回归分析得出,肿瘤分期、盆腔外放疗剂量是放疗后输尿管狭窄的独立危险因素。结论肿瘤分期高、盆腔外放疗剂量大可能是患者发生放疗后输尿管狭窄的独立危险因素。

Objective To explore the risk factors of ureteral stenosis after radiotherapy for cervical cancer.Method The clinical data of 163 patients with cervical cancer who underwent radiotherapy at our hospital during Jan.1,2013 and Jun.31,2018 were collected,and 14 relevant factors such as age,tumor stage(FIGO stage),synchronization,extra-pelvic radiotherapy dose,and preoperative hemoglobin were analyzed with univariate and multivariate Cox regression.Results Ureteral stenosis occurred in 20 patients(8.15%),including 3 cases on the left side,8 cases on the right side,and 9 cases bilaterally.Stenosis occurred during day 37 to day 2323(average 782.85).Univariate and multivariate Cox regression results showed that tumor stage and pelvic radiotherapy dose were independent risk factors for ureteral stenosis after radiotherapy.Conclusion Tumor stage and pelvic radiotherapy dose are independent risk factors for ureteral stenosis after radiotherapy.