1990—2019年江苏人群痛风疾病负担及其危险因素变化趋势

Study on thechanging trend of gout disease burden and its risk factors in Jiangsu population from 1990 to 2019

目的分析江苏人群痛风疾病负担及其危险因素变化趋势,为制定痛风防治策略提供指导。方法基于2019年全球疾病负担(GBD)数据库,采用伤残调整寿命年(DALYs)、患病率等指标,分析江苏省痛风疾病负担性别分布及其变化趋势,结合人群归因分值(PAF)分析痛风危险因素变化情况。结果与1990年相比,2019年江苏省痛风患病数增长184.44%,标化患病率增长35.00%,痛风造成的DALYs增长134.22%,标化DALYs率增长34.31%。1990—2019年,痛风标化患病率(t=6.70,P<0.01)、标化DALYs率(t=8.40,P<0.01)均呈上升趋势,不同性别、年龄组痛风人群患病水平和疾病负担均呈明显上升趋势(P值均<0.05)。2019年,由肾功能不全导致的痛风疾病负担增长38.88%,由高BMI导致的疾病负担增长145.27%。结论江苏省痛风疾病负担明显升高,应加强痛风的防治工作。

Objective To analyze the changing trend of gout disease burden and its risk factors in Jiangsu population;to provide guidance for making gout prevention and treatment strategies.Methods Based on the 2019 Global Burden of Disease(GBD)database,using indicators such as disability-adjusted life years(DALYs),prevalence and other indicators to analyze the gender distribution and changing trend of gout disease burden,combined with Population Attributable Score(PAF)to analyze changing trend of gout risk factors in Jiangsu Province.Results Compared with 1990,the number of gout patients in Jiangsu Province increased by 184.44%in 2019,the standardized prevalence rate increased by 35.00%,the DALYs caused by gout increased by 134.22%,and the standardized DALYs rate increased by 34.31%.From 1990 to 2019,both the standardized prevalence of gout(t=6.70,P<0.01)and the standardized DALYs rate(t=8.40,P<0.01)showed ascending trend;The prevalence and disease burden both showed significant ascending trend for groups of different genders and ages(all P<0.05).In 2019,the burden of gout disease caused by renal insufficiency and high BMI increased by 38.88%and 145.27%,respectively.Conclusion The burden of gout disease in Jiangsu Province increases,the prevention and treatment of gout should be strengthened.