PET影像组学在乳腺癌中的研究进展

Advance of PET radiomics on breast cancer

影像组学是近年来临床医学的热门研究课题,目前已在许多肿瘤中取得一些较满意的研究进展,其中包括乳腺癌。尽管传统影像学模式仍是当前诊断和评估乳腺癌的主要方法,但鉴于正电子发射体层成像(positron emission tomography,PET)/计算机体层成像(computed tomography,CT)或PET/磁共振成像(magnetic resonance imaging,MRI)影像组学因能同时显示形态和功能的高维特征信息而在乳腺癌的诊治过程中具有临床应用潜能和优势。最近,基于PET/CT或PET/MRI影像组学的乳腺癌研究报道如雨后春笋般涌现,特别是近两年来,PET影像组学在鉴别诊断、转移评估、分子分型预测、疗效监测和预后预测等方面都取得了一定的进步。因此,本文综述了PET/CT或PET/MRI影像组学在乳腺癌中的最新研究进展以及所面临的挑战和可能的解决方法。

In recent years,radiomics,as hot topic in the research of clinical medicine,has been widely explored in various tumors(including breast cancer)and achieved satisfying progresses.Although the traditional imaging modes remains most common methods for diagnosing and evaluating breast cancer,positron emission tomography(PET)/computed tomography(CT)or PET/magnetic resonance imaging(MRI)based radiomics represent great potential to clinical application for therapeutic and diagnostic purpose due to its ability of simultaneously presenting morphological and functional characteristics.Recently,the studies on PET/CT or PET/MRI based radiomics in breast cancer have emerging on the literature over the world,especially in the last two years,PET radiomics have made great progress in differential diagnosis,metastasis assessment,molecular typing prediction,efficacy of monitoring prediction and prognosis prediction.In this manuscript,a comprehensive review of PET/CT or PET/MRI based radiomics in breast cancer were provided,its facing challenges and possible solution were also included.