蟾蜍类制剂抗乳腺癌的作用及其机制研究进展

Anti-breast cancer effect and mechanism of toad preparations:research progress

蟾蜍类中药传统以内服经全身抗乳腺癌,或外敷以局部治疗晚期乳腺癌,但应用较少。近年研究显示,蟾蜍类中药制剂及单体具有多途径、多靶点抗肿瘤特性,其有效成分能诱导乳腺癌细胞凋亡、抑制细胞增殖及增敏化疗药物实现耐药逆转,有良好的抗乳腺癌效果。本文对蟾蜍类中药制剂和有效单体的抗乳腺癌效果和机制进行综述,认为蟾蜍类中药制剂和有效单体能通过2种途径诱导乳腺癌细胞凋亡,有效单体蟾毒灵联合化疗能起到减毒增效及耐药逆转作用。

As a kind of traditional Chinese medicine,toad is used to treat breast cancer systemically by oral administration or treat advanced breast cancer locally by external application,yet it is rarely used.Recent studies have shown that toad preparations and monomers have multi-pathway and multi-target anti-tumor properties.Their effective components can induce apoptosis of breast cancer cells,inhibit cell proliferation,and sensitize chemotherapy drugs to achieve drug resistance reversal,showing good anti-breast cancer effects.This paper reviews the anti-breast cancer effect and mechanism of toad preparations and effective monomers.Toad preparations and its effective monomers can induce apoptosis of breast cancer cells through 2 ways,and effective monomer bufalin can reduce toxicity,enhance efficacy,and reverse drug resistance in combination with chemotherapeutic drugs.