基于肠道菌群探讨中医药治疗帕金森病的研究进展

Research Progress of Parkinson’s Disease Treated with Traditional Chinese Medicine Based on Intestinal Flora

帕金森病(PD)是常见的神经系统退行性疾病,65岁以上人群患病率3.7%,随着全球人口老龄化进程的持续加剧,PD已演变为全球负担。目前已知PD主要病理特征为纹状体多巴胺(DA)缺乏,中脑黑质DA能神经元的退化以及路易小体(Lewy body)的形成;但PD的病因及发病机制尚不明确。肠道菌群被称为人体的“第二基因组”,参与了代谢、消化、炎症及免疫等多项生理功能的调节。近年来肠道菌群在PD中的作用引起了广泛关注,有研究认为PD主要病理标志物α-突触核蛋白可能起源于肠道,肠道菌群的失调影响PD的病程进展。中医药治疗帕金森病的优势逐渐显现,基于肠道菌群理论,综述中医药治疗帕金森病的研究进展,以期有助于帕金森病的临床诊断和治疗。参考文献64篇。

Parkinson’s disease(PD)is a common neurodegenerative disease.The prevalence rate in people over 65 years old is as high as 1%.With the aging population becoming more and more,PD has turned into a global burden.At present,the main pathological features of PD are dopamine(DA)deficiency in the striatum,the degeneration of DA neurons in the substantia nigra of the midbrain,and the formation of Lewy body.However,the etiology and pathogenesis of PD are still unclear.Intestinal flora,known as the“second genome”of the human body,is involved in the regulation of many physiological functions,such as metabolism,digestion,inflammation and immunity.In recent years,the role of intestinal flora in PD has attracted more and more attention.According to some studies,in PD the major pathological markerα-synuclein may originate from the intestine,and the imbalance of intestinal flora affects the progression of PD.Traditional Chinese medicine(TCM)has gradually showed certain advantages in the PD treatment of PD.In this paper the research progress of PD treated with TCM based on intestinal flora theory were reviewed,so as to promote the clinical diagnosis and treatment of PD.Sixty-four papers are cited in the references.