川崎病流行病学及分子学研究进展

Progress in epidemiology and molecular studies of Kawasaki disease

川崎病好发于5岁以下的儿童,主要累及全身中小血管,冠状动脉扩张及冠状动脉瘤是其常见的严重并发症。近年来川崎病的发病率逐年增高,已逐渐成为发达国家儿童获得性心脏病的主要病因之一。迄今为止,川崎病的发病机制仍不明确,诊断川崎病主要依靠临床特点及影像学检查。本文将重点围绕近年来关于川崎病流行病学及分子学的研究进行综述,以期为川崎病的临床诊疗提供帮助。

Kawasaki disease usually occurs in children under 5 years of age and mainly involves small and medium blood vessels in the whole body.Common serious complications include coronary artery dilation and coronary aneurysm.The incidence of Kawasaki disease has been increasing year by year in recent years,and it has gradually become one of the main causes of acquired heart disease in children in developed countries.At present,the pathogenesis of Kawasaki disease is not clear,and the diagnosis of Kawasaki disease mainly depends on clinical characteristics and imaging examination.Therefore,this review will focus on recent studies on the epidemiology and molecular science of Kawasaki disease,to contribute to the clinical diagnosis and treatment of Kawasaki disease.