血清铁蛋白、谷氨酰转肽酶、腺苷脱氨酶和5′-核苷酸酶联合检测对肝癌的诊断价值

Diagnostic value of combined detection of serum ferritin,glutamyl transpeptidase,adenosine deaminase and 5′-nucleotidase in liver cancer

目的研究血清铁蛋白(SF)、谷氨酰转肽酶(GGT)、腺苷脱氨酶(ADA)和5′-核苷酸酶(5′-NT)联合检测对肝癌的诊断价值。方法选取2020年4月至2022年3月于新疆医科大学附属中医医院治疗的200例肝癌患者作为肝癌组,选取同期195例肝良性肿瘤患者作为良性组。采集两组空腹静脉血4 ml,测定并比较两组患者的SF、GGT、ADA及5′-NT水平,以病理诊断结果作为金标准,计算SF、GGT、ADA及5′-NT单项及联合诊断肝癌的一致性及敏感度、特异度、准确度。结果肝癌组患者的SF、GGT、ADA及5′-NT水平高于良性组,差异有统计学意义(P<0.05)。以病理诊断结果作为金标准,SF+GGT+ADA+5′-NT诊断肝癌结果与病理结果的一致性优于SF、GGT、ADA及5′-NT。SF+GGT+ADA+5′-NT联合诊断的敏感度、准确度高于SF、GGT、ADA及5′-NT单项检测结果,差异有统计学意义(P<0.005);SF、GGT、ADA及5′-NT单项及联合诊断肝癌的特异度比较,差异无统计学意义(P>0.005);SF、GGT、ADA及5′-NT单项检测的敏感度及特异度、准确度比较,差异无统计学意义(P>0.005)。结论肝癌患者的血清SF、GGT、ADA和5′-NT水平升高,且联合检测SF、GGT、ADA和5′-NT能够提高肝癌诊断敏感度,诊断效能较高。

Objective To study the diagnostic value of serum ferritin(SF),glutamyltranspeptidase(GGT),adenosine deaminase(ADA)and 5′-nucleotidase(5′-NT)in the diagnosis of liver cancer.Methods A total of 200 patients with liver cancer treated in Xinjiang Medical University Affiliated Hospital of Traditional Chinese Medicine from April 2020 to March 2022 were selected as the liver cancer group,and 195 patients with benign liver tumors during the same period were selected as the benign group.The levels of SF,GGT,ADA and 5′-NT were measured and compared between the two groups.The pathological diagnosis results were used as the gold standard to calculate the consistency,sensitivity,specificity and accuracy of SF,GGT,ADA and 5′-NT in single and combined diagnosis of liver cancer.Results The levels of SF,GGT,ADA and 5′-NT in liver cancer group were higher than those in benign group,and the differences were statistically significant(P<0.05).Taking pathological diagnosis results as the gold standard,the consistency between SF+GGT+ADA+5′-NT and pathological results was better than that of SF,GGT,ADA and 5′-NT.The sensitivity and accuracy of SF+GGT+ADA+5′-NT combined diagnosis were higher than those of SF,GGT,ADA and 5′-NT alone,the differences were statistically significant(P<0.005).There was no statistically significant difference in the specificity of SF,GGT,ADA and 5′-NT in the diagnosis of hepatocellular carcinoma(P>0.005).There were no statistically significant differences in the sensitivity,specificity and accuracy of SF,GGT,ADA and 5′-NT(P>0.005).Conclusion The serum levels of SF,GGT,ADA and 5′-NT in patients with liver cancer are increased,and the combined detection of SF,GGT,ADA and 5′-NT can improve the diagnostic sensitivity of liver cancer,and the diagnostic efficiency is high.