急性上呼吸道感染与血清谷丙转氨酶的相关性分析

Correlation Analysis between acute upper respiratory Tract Infection and Serum Alanine Aminotransferase

目的比较急性上呼吸道感染(上感)患者和正常人血清谷丙转氨酶(ALT)的区别,进行急性上感和ALT的相关性分析。方法收集2020年2月至2020年5月发热病房的上呼吸道感染60例患者为观察组和及体检中心的筛查正常报告40例做对照组,收集血常规、C-反应蛋白(CRP)、降钙素原(PCT)、谷丙转氨酶(ALT)、谷草转氨酶(AST)等项目,进行两组间临床资料的比较,并进行两组Logistic回归分析。结果两组比较,观察组的血小板(PLT)[(174.81±56.99)×10^(9)/L]、淋巴细胞(LYM)[(1.56±0.84)×10^(9)/L]、单核细胞(MONO)[(0.57±0.26)×10^(9)/L]、中性粒细胞与淋巴细胞比值(NLR)(3.40±2.41)、CRP[(25.96±24.47)mg/L]、谷丙转氨酶(ALT)[(68.72±53.12)U/L]、谷草转氨酶(AST)[(45.44±32.80)U/L],与对照组[(220.61±42.91)×10^(9)/L、(1.96±0.57)×10^(9)/L、(0.42±0.10)×10^(9)/L、(1.98±0.73)、(7.10±2.17)mg/L、(27.53±19.96)U/L、(22.33±8.24)U/L]比较,差异有统计学意义(t=-4.508,-2.539,3.836,4.230,5.112,5.367,5.131,均P<0.05)。以是否出现急性上感为因变量,其他因素为自变量,进行Binary Logisitic回归分析(Forward:Wald),其中LYM、ALT、CRP与急性上感明显相关,差异有统计学意义(P<0.05)。结论急性上感与血清ALT具有相关性,且急性上感患者ALT明显增高。

Objective To compare the difference of serum alanine aminotransferase(ALT)between patients with acute upper respiratory tract infection(upper flu)and normal people,and analyze the correlation between acute upper flu and ALT.Methods A total of 60 patients with upper respiratory tract infection in the fever ward from February 2020 to May 2020 were collected as the observation group and 40 normal screening reports from the physical examination center as the control group.Blood routine,C-reactive protein(CRP),procalcitonin(PCT),alanine transaminase(ALT),aspartate aminotransferase(AST)and other items were collected,and the clinical data between the two groups were compared,and the two groups were analyzed by Logistic regression.Results Compared with the two groups,in observation group PLT[(174.81±56.99)×10^(9)/L],lymphocyte(LYM)[(1.56±0.84)×10^(9)/L],monocyte(MONO)[(0.57±0.26)×10^(9)/L],neutrophil to lymphocyte ratio(NLR)(3.40±2.41),CRP[(25.96±24.47)mg/L],alanine aminotransferase(ALT)[(68.72±53.12)U/L],aspartate aminotransferase(AST)[(45.44±32.80)U/L],and those in the control group[(220.61±42.91)×10^(9)/L、(1.96±0.57)×10^(9)/L、(0.42±0.10)×10^(9)/L,(1.98±0.73),(7.10±2.17)mg/L,(27.53±19.96)U/L,(22.33±8.24)U/L],the difference was statistically significant(t=-4.508,-2.539,3.836,4.230,5.112,5.367,5.131,all P<0.05).Binary logistic regression(forward:Wald)was carried out with whether there was acute allergy as the dependent variable and other factors as the independent variable.Among them,LYM,ALT and CRP were significantly correlated with acute allergy(P<0.05).Conclusion There is a correlation between acute upper infection and serum ALT,and ALT in patients with acute upper infection is significantly increased.