中药调控膝骨关节炎细胞自噬实验研究进展

Current Status of Experimental Research on the Regulation of Autophagy by Traditional Chinese Medicine in Knee Osteoarthritis

膝关节骨性关节炎(KOA)具有发病率高、难以逆转、致残率高等特点,造成了本病治疗效果不理想、治疗成本偏高,给患者带来过重心理负担等问题。自噬是维持软骨细胞内环境稳态的关键环节,自噬失调导致的软骨代谢异常是KOA发病的重要机制。近年来,在中药复方、单方及其有效成分防治KOA方面进行了大量的基础和临床研究。文章综述近年来国内外报道的通过中药复方、单方及其有效成分调控自噬干预膝骨关节炎的研究,以期为进一步的研究提供依据。

Osteoarthritis of the knee(KOA)has the characteristics of high incidence,difficult to reverse,high disability rate,resulting in the treatment of the disease is not ideal,high cost,heavy psychological burden and other problems.Autophagy is a key link in maintaining the homeostasis of the chondrocyte environment,and the abnormal cartilage metabolism caused by autophagy disorder is an important mechanism for the pathogenesis of KOA.In recent years,a large number of basic and clinical studies have been conducted on the prevention and treatment of KOA by traditional Chinese medicine and its active ingredients.In order to provide the basis for further research,this paper reviewed the recent domestic and foreign reports on the intervention of knee osteoarthritis by Chinese herbal formula,monomechanical formula and its effective components through regulating autophagy.