Chemerin在合并2型糖尿病口腔鳞癌患者肿瘤中的表达及临床意义

Expression and clinical significance of chemerin in oral squamous cell carcinoma patients combined with type 2 diabetes

目的:探讨chemerin在合并2型糖尿病口腔鳞癌(T2DM-OSCC)患者肿瘤组织中的表达及临床意义,分析其与临床病理参数及预后的关系,为T2DM-OSCC患者的治疗提供理论依据。方法:收集2009年1月—2014年12月在青岛大学附属医院口腔颌面外科收治的T2DM-OSCC患者(87例)和普通OSCC患者(113例),利用免疫组织化学(IHC)方法检测2组肿瘤及癌旁组织中chemerin的表达,采用SPSS 26.0软件包对数据进行统计学分析。结果:T2DM-OSCC患者肿瘤组织中chemerin的表达显著高于癌旁组织(P<0.05),其高表达与颈淋巴结转移、TNM分期、肿瘤分化程度和肿瘤复发相关(P<0.05)。T2DM-OSCC患者肿瘤组织中chemerin表达显著高于普通OSCC患者(P<0.05)。合并2型糖尿病chemerin高表达组术后5年总生存率显著低于其他组(P<0.05),肿瘤组织中chemerin表达是影响T2DM-OSCC患者5年总生存率的独立预后因素。结论:Chemerin在T2DM-OSCC中的表达较普通OSCC高,其高表达提示T2DM-OSCC患者的预后更差。Chemerin有望成为T2DM-OSCC患者判断预后的潜在指标和治疗靶点。

PURPOSE:To explore the expression and clinical significance of chemerin in oral squamous cell carcinoma(OSCC)patients with type 2 diabetes(T2DM),analyze the relationship with clinicopathological characteristics and progno-sis,in order to provide evidence for further postoperative treatment of OSCC patients with T2DM(T2DM-OSCC).METHODS:OSCC specimens combined with type 2 diabetes and without type 2 diabetes(general OSCC)were selected from the Department of Oral and Maxillofacial Surgery of the Affiliated Hospital of Qingdao University from January 2009 to De-cember 2014.Chemerin expression levels in tumors and para-cancerous tissues were detected by immunohistochemistry(IHC),SPSS 26.0 software package was used for data analysis.RESULTS:In the T2DM-OSCC patients,chemerin expression was significantly higher in tumor tissues compared with para-cancerous tissues(P<0.05)and chemerin expression was associated with cervical lymph node metastasis,higher TNM stage,lower tumor differentiation,and tumor recurrence(P<0.05).Chemerin expression in tumor tissues of T2DM-OSCC patients was significantly higher than that in ordinary OS-CC patients(P<0.05).Log-Rank analysis and Kaplan-Meier analysis showed that the 5-year OS was shorter in the group of high chemerin expression combined with type 2 diabetes than other three groups(P<0.05).Cox model showed that chemerin expression in tumor tissues was an independent prognostic factor(P<0.05)affecting OS of T2DM-OSCC patients.CONCLUSIONS:Chemerin expression was higher in T2DM-OSCC patients than in ordinary OSCC,high expression of chemerin suggests poor prognosis in T2DM-OSCC patients.Chemerin is expected to be a potential indicator and target molecule for judging the prognosis of T2DM-OSCC patients.