宫颈癌治疗后下肢淋巴水肿的危险因素及预防

Risk factors and prevention of lower extremity lymphedema after treatment for cervical cancer

宫颈癌是女性生殖系统常见的恶性肿瘤,常采用手术和放化疗相结合的综合治疗。下肢淋巴水肿(LEL)是宫颈癌治疗后的常见并发症,严重影响患者的生活质量。宫颈癌手术和放疗均可导致LEL的发生,且LEL的危险因素复杂,涉及患者因素(年龄、合并慢性疾病、生活习惯等)、疾病因素[国际妇产科联盟(FIGO)分期和淋巴结转移]和治疗因素(淋巴结切除数量、旋髂深淋巴结的切除、辅助治疗等)。针对生活方式和治疗因素的综合性预防措施有望减少宫颈癌患者LEL的发生,但LEL预防措施及其有效性还亟待进一步研究。

Cervical cancer is a common malignant tumor of female reproductive system.The treatment of cervical cancer is based on surgery and radiotherapy(or concurrent chemoradiation).Lower extremity lymphedema(LEL)is a frequent complication after cervical cancer treatment,which significantly affects the quality of life of patients.Both pelvic surgery and radiation for cervical cancer can lead to LEL.The risk factors for LEL are complicated and involving characteristics regarding patient(age,comorbidities,lifestyle,etc.),tumor[International Federation of gynecology and Obstetrics(FIGO)stage,lymph node metastasis,etc.],and treatment(number of resected lymph nodes,removal of circumflex iliac nodes,adjuvant therapy,etc.).Comprehensive measures are proposed to prevent cervical cancer patients from LEL,and further investigations in terms of effectiveness are warranted.