SGLT-2抑制剂对心血管保护作用的研究概况

Research Progress on Cardiovascular Protection of SGLT-2 Inhibitors

钠-葡萄糖协同转运蛋白-2(SGLT-2)抑制剂是一类新型的治疗2型糖尿病的药物,降糖效果好,不良反应发生率低,近年来有研究发现,除降糖作用以外,SGLT-2抑制剂还具有心血管保护作用。本文将从对心血管危险因素的影响、对肾脏的影响、降低尿酸、减少炎症、改善心脏能量代谢以及预防心脏重构等方面概述SGLT-2抑制剂的心血管保护作用。

Sodium-glucosecotransporter-2(SGLT-2)inhibitors are a new class of drugs in the treatment of type 2 diabetes.Hypoglycemic effect was well,the incidence of adverse reactions was low.In recent years,studies have found that in addition to hypoglycemic effects,SGLT-2 inhibitors also have cardiovascular protective effects.This paper will summarize the cardiovascular protective effects of SGLT-2 inhibitors from the aspects of effects on cardiovascular risk factors and kidneys,lowering blood pressure,lowering uric acid,reducing inflammation,improving cardiac energy metabolism,and preventing cardiac remodeling.