某院2018-2020年抗抑郁药物的应用分析

Analysis on the Use of Antidepressants in a Hospital from 2018 to 2020

目的:评价并分析抗抑郁药的应用情况,为临床合理用药提供参考。方法:从某院药品管理系统中调取2018—2020年抗抑郁药物的使用量、销售金额等信息,计算用药频度(DDDs)、限定日费用(DDC)和销售金额排序与用药频度排序的比值(B/A)。结果:2018—2020年,某院抗抑郁药的总体销售金额呈升高趋势,临床上主要使用选择性5-羟色胺再摄取抑制剂(Selective serotonin reuptake inhibitors,SSRIs)与5-羟色胺和去甲肾上腺素再摄取抑制剂(Serotonin norepinephrine reuptake inhibitors,SNRIs)类抗抑郁药物。舍曲林、度洛西汀、文拉法辛和坦度螺酮的DDDs值基本稳居前5,而帕罗西汀、艾司西酞普兰、氯米帕明的DDDs值下降。除帕罗西汀、艾司西酞普兰外其他各类药物的DDC值基本保持稳定。2018—2020年内更多抗抑郁药物的B/A值等于或接近1。结论:该院抗抑郁药物的使用情况基本合理,新型抗抑郁药物或将成为临床首选。

Objective:The clinical application of antidepressants were investigated and analyzed in the hospital to provide reference for clinical rational drug use.Methods:The quantity and sales amount of antidepressants in 2018-2020 were retrieved from information management system of the hospital.Defined daily dose system(DDDs),defined daily cost(DDC),and Ratio of sequence of sales amount and sequence of DDDs(B/A)were calculated.Results:During 2018 to 2020 the overall sales amount of antidepressants in the hospital showed an upward trend.Serotonin reuptake inhibitors(SSRIs)and serotonin and norepinephrine reuptake inhibitors(SNRIs)were selected in clinical practice.The DDDs rankings of sertraline,duloxetine,venlafaxine and tandospirone were basically top five,while the DDDs values of paroxetine,escitalopram and clomipramine decreased.Except for paroxetine and escitalopram,the DDC values of other drugs remained stable.More antidepressants had B/A values(1or near 1)in 2018-2020.Conclusion:The use of antidepressant drugs in this hospital is basically reasonable and new antidepressant drugs may become the first choice in clinical practice.