输血相关急性肺损伤

Transfusion-related acute lung injury

输血相关急性肺损伤(TRALI)是危及生命的输血急性并发症。TRALI是临床综合征,主要根据临床表现诊断。TRALI的发病机制尚不明确,二次打击模式假说被普遍接受。TRALI的治疗以对症支持为主,尚无针对性的特效治疗。合理用血是避免TRALI的基本措施。实施以避免输注多产次女性献血者血浆成分为主的预防措施降低了TRALI发病率。

Transfusion-related acute lung injury(TRALI)is an acute and fatal complication of blood product transfusion.TRALI is a syndrome,which diagnosed by the basis of clinical signs.The pathogenesis of TRALI is unclear and the hypothesis of two-hit model is generally accepted.At present,there is no specific treatment for TRALI.Treatment of the patient with TRALI is mainly supportive.The rational transfusions can avoid the occurrence of TRALI.The incidence of TRALI has been decreased by making the mainly measure of avoiding transfusions of plasma from multiparous female donors.