神经重症儿童交感神经介导的应激性心肌病研究进展

Progress of takotsubo mediated by sympathetic nervous in children with intensive nervous system disease

儿童神经重症发病率高,远期或多或少会留下后遗症。且由于年龄关系,长期治疗费用多,给患儿家庭和社会造成极大负担。神经重症发生时,机体可表现为交感神经活性增加,儿茶酚胺升高,从而导致应激性心肌病的发生。应激性心肌病发生后,可致颅内氧气供给减少,从而加重神经重症疾病,使患儿不良临床结局加重。通过镇静镇痛以降低交感神经活性等方案可以达到治疗神经重症疾病及应激性心肌病的目的。

The incidence of intensive nervous system disease in children is high,and there will be more or less long-term sequelae.In addition,due to age,long-term treatment costs are high,causing a great burden to society.When intensive nervous system disease occurs,the body can show an increase in sympathetic activity and catecholamine,which leads to the occurrence of takotsubo.After the occurrence of takotsubo,it can reduce the supplement of intracranial oxygen,thus aggravate the intensive nervous system disease and aggravate the adverse clinical outcome of children.Sedation and analgesia to reduce sympathetic activity can achieve the purpose of treating intensive nervous system diseases and takotsubo.