布氏锥虫的蛋白质翻译后修饰研究进展

Progress on Posttranslational Modifications of Proteins in Trypanosoma brucei

生物体在生命周期中要经历蛋白质翻译后修饰,其具有增加蛋白质组的复杂性、改变相关蛋白质的定位、促进或阻止蛋白质之间的相互作用、激活或失活相关蛋白质等作用。在布氏锥虫中存在许多蛋白质翻译后修饰,多样的修饰类型及所修饰的蛋白质起到调节布氏锥虫相关细胞功能的作用。论文就布氏锥虫的蛋白质翻译后修饰及相关功能的研究做一综述,以期为布氏锥虫病新药物靶点的发现及研究提供参考。

Organisms undergo post-translational modification in their life cycle,which can increase the complexity of proteome,change the localization of related proteins,promote or prevent the interaction between proteins,activate or inactivate related proteins and so on.There are many posttranslational modifications of proteins in Trypanosoma brucei.Various modification types and modified proteins play roles in regulating the cellular functions of Trypanosoma brucei.This review briefly summarizes the research on protein post-translational modification and related functions of Trypanosoma brucei,in order to provide reference for the discovery and research of new drug targets of trypanosomiasis.