百乐眠联合氯吡格雷、低分子肝素治疗进展性脑梗死伴睡眠障碍效果研究

Study on the Effect of Bailemian Combined with Clopidogrel and Low Molecular Weight Heparin in the Treatment of Progressive Cerebral Infarction with Sleep Disturbance

目的:探讨百乐眠联合氯吡格雷、低分子肝素治疗进展性脑梗死伴睡眠障碍患者的临床效果。方法:选取2019年1月-2021年12月东莞市万江医院收治的60例进展性脑梗死伴睡眠障碍患者作为研究对象,按随机数表法分为两组,各30例。对照组采用氯吡格雷、低分子肝素治疗,观察组在对照组基础上加用百乐眠治疗。比较两组肾上腺素(EPH)、多巴胺(DA)、5-羟色胺(5-HT)水平及睡眠状况、不良反应发生情况。结果:治疗后,观察组EPH、DA、5-HT水平均低于对照组,差异有统计学意义(P<0.05)。观察组夜间觉醒次数少于对照组,总睡眠时间长于对照组,睡眠潜伏期短于对照组,匹兹堡睡眠质量指数评分低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:百乐眠联合氯吡格雷、低分子肝素治疗进展性脑梗死伴睡眠障碍患者,可降低神经递质水平,提高睡眠质量,且安全可靠。

Objective:To investigate the clinical effect of Bailemian combined with clopidogrel and low molecular weight heparin in the treatment of patients with progressive cerebral infarction with sleep disturbance.Methods:From January 2019 to December 2021,60 patients with progressive cerebral infarction and sleep disorders who were admitted to Wanjiang Hospital in Dongguan City were selected as the research objects.According to the random number table method,they were divided into two groups,each with 30 cases.The control group was treated with clopidogrel and low molecular weight heparin.On the basis of the control group,the observation group was additionally treated with Bailesian.The levels of epinephrine(EPH),dopamine(DA),serotonin(5-HT),sleep status,and adverse reactions were compared between the two groups.Results:After treatment,the levels of EPH,DA and 5-HT in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The number of nighttime awakenings in the observation group was less than that in the control group,the total sleep time was longer,the sleep latency was shorter than that in the control group,and the Pittsburgh Sleep Quality Index score was lower than that in the control group,with statistically significant differences(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Bailemian combined with clopidogrel and low molecular weight heparin in the treatment of patients with progressive cerebral infarction and sleep disorders can reduce the level of neurotransmitters and improve sleep quality,and it is safe and reliable.