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孟鲁司特钠联合糖皮质激素吸入治疗对咳嗽变异性哮喘患儿IgE、EOS及IL-10的影响 被引量:4

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摘要 目的:分析孟鲁司特钠联合糖皮质激素吸入治疗对咳嗽变异性哮喘(Cough Variant Asthma,CVA)患儿免疫球蛋白E(Immunoglobulin E,IgE)、嗜酸性粒细胞(Eosinophil,EOS)及白细胞介素-10(Interleukin-10,IL-10)的影响。方法:选取2019年12月至2022年3月本院收治的CVA患者98例,根据治疗方法不同分为对照组(糖皮质激素吸入治疗)47例和观察组(糖皮质激素吸入联合孟鲁司特钠治疗)51例。对比两组临床疗效、IgE、EOS、IL-10水平和不良反应发生情况。结果:观察组临床总疗效(88.24%)明显高于对照组(63.83%),具有统计学差异(P<0.05)。观察组治疗后IgE、EOS指标值均低于对照组,IL-10水平高于对照组(P<0.05)。两组不良反应发生情况比较无统计学差异(P>0.05)。结论:孟鲁司特钠联合糖皮质激素吸入治疗CVA患儿有显著的临床效果,且安全性较高,可有效降低IgE、EOS指标值,升高IL-10水平,缓解咳嗽症状,改善肺功能。
出处 《四川生理科学杂志》 2022年第8期1425-1427,共3页 Sichuan Journal of Physiological Sciences
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