肿瘤酸性微环境下肝细胞癌发生发展机制的研究进展

Research progress on the mechanism of hepatocarcinogenesis and development in tumor acidic environment

原发性肝细胞癌(HCC)是国内高发的实体肿瘤之一,尽管目前对HCC的综合治疗模式研究越发成熟,但患者的5年生存率仍然较低,根本原因在于对HCC的进展和侵袭转移研究无法突破。近年的研究发现,肿瘤酸性微环境可能会推动HCC的进展和复发转移。本文结合国内外文献,对肿瘤酸性环境下HCC发生发展机制的相关研究作一综述。

Primary hepatocellular carcinoma(HCC)is one of the high-risk solid tumors in China.Although there has been more comprehensive progress on HCC caricinogenesis,migration and invasion,the 5-year survival is still poor.In recent years,it has been identified that tumor acidic microenvironment may promote the occurrence and development of hepatocellular carcinoma.In this paper,combined with the latest research at home and abroad,the research progress on the occurrence and development of hepatocellular carcinoma under an acidic environment was reviewed.