经颅微电流刺激对抑郁症患者睡眠的影响

Effect of cranial electrotherapy stimulation on sleep of patients with depression

目的研究经颅微电流刺激(CES)对抑郁症患者睡眠的影响。方法入组64例符合《国际疾病分类》第10版中抑郁症诊断标准的患者,将其随机分为常规组与CES组。常规组患者接受8周抗抑郁药物草酸艾司西酞普兰治疗;CES组患者在草酸艾司西酞普兰治疗基础上接受8周CES治疗,观察治疗前后汉密尔顿抑郁量表(HAMD)、多导睡眠图指标的变化。结果治疗后多导睡眠图提示CES组较常规组睡眠潜伏期缩短、总睡眠时间延长,非快速眼球运动睡眠2期及快速眼球运动期睡眠时间和比例增加,差异有统计学意义(P<0.05);CES组HAMD评分较常规组低,差异有统计学意义(P<0.05)。结论CES对抑郁症患者睡眠质量有较好的改善作用。

Objective To investigate the effect of cranial electrotherapy stimulation(CES)on sleep in patients with depression.Methods Sixty-four patients with depression diagnosed according to International Classification of Disease(10th Revision)were randomly divided into two groups,conventional group and CES group.Patients in the conventional group were treated with escitalopram oxalate for 8 weeks,and patients in the CES group were treated with CES for 8 weeks on the basis of escitalopram oxalate.Before and after the treatment,we observed the changes in HAMD-17 and polysomnography indexes.Results After 8-week treatment,polysomnography showed that compared with the conventional group,the sleep latency was shortened,the total sleep time was prolonged,and the sleep time and proportion of N2 and REM phase were increased in the CES group,with statistical difference(P<0.05);the HAMD score of the CES group was lower than that of the conventional group,and the difference was statistically significant(P<0.05).Conclusion CES can improve the sleep quality of patients with depression.