血清Chemerin、NGAL水平与乙肝肝硬化患者疾病转归的相关性研究

The correlation between serum chemerin and NGAL and disease outcome in patients with hepatitis B cirrhosis

目的:探究血清趋化素(Chemerin)、中性粒細胞明胶酶相关脂质运载蛋白。(NGAL)水平变化与乙肝肝硬化患者疾病转归的相关性研究。方法:选取医院收治乙肝肝硬化患者80例作为研究对象(选取时间:2019年2月~2021年3月)作为研究组,另纳入同期在本院进行健康体检的健康者30例,作为对照组,对比两组患者血清中Chemerin、NGAL水平;在治疗后,对乙肝肝硬化患者进行肝疾病严重程度评分系统(CTP)分级,根据评分结果将其分为预后良好组和预后不良组,并采用单因素及多因素logistic回归分析及Pearson相关性分析,探讨血清Chemerin、NGAL水平变化与乙肝肝硬化患者疾病转归的相关性。结果:相较对照组,研究组患者血清Chemerin水平明显偏低,NGAL明显偏高(P<005);80例乙肝肝硬化患者,预后良好组53例,预后不良组27例,其中预后良好组患者年龄、血压水平、CTP评分、NGAL水平均较预后不良组低,Chemerin水平较预后不良组高(P<005);经Logistic回归分析,结果显示,CTP评分、Chemerin水平、NGAL水平变化可作为评估患者疾病转归的的独立影响因素(P<0.05);经Pearson分析结果显示,血清Chemerin水平变化与CTP评分星负相关(r=-0370);血清NGAL水平变化与CTP评分呈正相关(r=0.412)。结论:Chemerin、NGAL水平均在乙肝肝硬化患者血清中呈现异常表达,与CTP评分有显著相关性,可作为评估患者病情变化的有效临床指标,动态监测可作为评估患者病情及转归提供科学依据。

Objective:To explore the correlation between serum chemokinin(Chemerin)and neutrophil gelatinase-associated lipocahn(NGAL)levels and the disease outcome of patients with hepatitis B cirrhosis.Methods:A total of 80 patients with hepatitis B and cirrhosis admitted to the hospital were selected as the research objects(selection time:February 2019-March 2021)as the research group.In addition,30 healthy people who underwent physical examination in our hospital during the same period were included as the control group.The levels of chemerin and NGAL in serum between the two groups were compared.After treatment;patients with hepatitis B cirrhosis were graded by liver disease severity scoring system(CTP),and they were divided into a good prognosis group and a poor prognosis group according to the score.Univariate and multivariate logistic regression analysis and Pearson correlation analysis were used to explore the correlation between the changes of serum Chemerin and NGAL levels and the disease outcome of patients with hepatitis B cirrhosis.Results:Compared with the control group,the serum Chemerin level in the study group was significandy lower,and the NGAL was significandy higher(P<0.05).Of the 80 patients with hepatitis B cirrhosis,53 were in the good prognosis group and 27 in the poor prognosis group.The age,blood pressure,CTP score and NGAL level of the patients in the good prognosis group were lower than those in the poor prognosis group,and the Chemerin level was higher than those in the poor prognosis group(P<0.05).Logistic regression analysis showed that the changes of CTP score,Chemerin level and NGAL level could be used as independent influencing factors for evaluating the disease outcome of patients(P<0.05);The results of Pearson analysis showed that the change of serum Chemerin level was negatively correlated with CTP score(r=-0.370),the change of serum NGAL level was positively correlated with CTP score(r=0.412).Conclusion:The levels of Chemerin and NGAL were abnormally expressed in the serum of patients with hepatitis B cirrhosis,and were significandy correlated with the CTP score.They can be used as effective clinical indicators to evaluate the changes of patients'condition.Dynamic monitoring can be used as a scientific basis for evaluating the patient's condition and prognosis.