STING信号通路在缺血-再灌注损伤中的作用研究进展

Research progress on the role of STING signal pathway in ischemia-reperfusion injury

缺血-再灌注损伤(IRI)是一种广泛存在于器官移植、外科手术中的病理生理过程,主要表现为器官或组织缺血期发生缺氧损伤,恢复灌注后损伤反而进一步加重。缺血-再灌注诱发组织细胞损伤,释放损伤相关分子模式,进一步通过模式识别受体激活多种免疫细胞,导致无菌性炎症,加重组织损伤。环磷酸鸟苷-腺苷酸合成酶(cGAS)作为模式识别受体中的重要成员,可激活干扰素基因刺激因子(STING)信号通路,在先天免疫应答中具有重要调控作用。目前,越来越多的证据表明cGAS-STING信号通路在器官IRI中发挥了重要作用。本文将针对STING信号通路及其在不同器官IRI中的作用和机制展开综述,以期为临床干预提供新的思路。

Ischemia-reperfusion injury(IRI) is a pathophysiological process, which widely exists in organ transplantation and surgery. IRI is mainly manifested with hypoxia injury of organs or tissues during the ischemia period,which could be further aggravated after reperfusion. Ischemia-reperfusion induces tissue cell injury, releases damageassociated molecular pattern and further activates multiple immune cells via pattern recognition receptor, leading to aseptic inflammation and aggravating tissue injury. Cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS),as a critical member of pattern recognition receptor, could activate the stimulator of interferon genes(STING) signal pathway and play an important regulatory role in innate immune response. At present, increasing evidences have shown that cGAS-STING signal pathway plays a significant role in organ IRI. In this article, STING signaling pathway, its role and mechanism in IRI of different organs were reviewed, aiming to provide novel ideas for clinical interventions.