中医药在核苷(酸)类似物治疗慢性乙型肝炎中的作用

Role of traditional Chinese medicine in treatment of chronic hepatitis B by nucleos(t)ide analogues

核苷(酸)类似物可抑制HBV复制,有效治疗慢性乙型肝炎,却无法彻底根除HBV,无法阻止低病毒载量下乙型肝炎肝硬化、肝癌的发展。近年来中药在慢性乙型肝炎的治疗中应用广泛,阐述了中药抑制HBV复制,降低HBeAg含量,延缓乙型肝炎肝硬化、肝癌发展等方面的应用及机制,提出中医药可提高核苷(酸)类似物治疗慢性乙型肝炎的疗效。

Nucleos(t)ide analogues(NUC)can inhibit the replication of hepatitis B virus(HBV)and effectively treat chronic hepatitis B(CHB),but they cannot completely eradicate HBV and cannot prevent the progression to hepatitis B cirrhosis and liver cancer in the context of a low viral load.In recent years,traditional Chinese medicine has been widely used in the treatment of CHB.This article elaborates on the application and mechanism of traditional Chinese medicine in inhibiting HBV replication,reducing the content of HBeAg,and delaying the progression to hepatitis B cirrhosis,and it is proposed that traditional Chinese medicine can improve the therapeutic effect of NUC in the treatment of CHB.