沸石咪唑类骨架负载黄芩素纳米材料的构建及释药研究

Study on the construction and drug release of the baicalein loaded on zeolitic imidazolate framework-based nanomaterials

黄芩素(baicalein)为黄酮类化合物,具有抗肿瘤活性。采用原位封装法,在室温条件下设计合成了一种负载黄芩素的沸石咪唑类骨架纳米材料(Baicalein@ZIF-8),并对其结构进行表征。试验结果显示,该方法合成的纳米材料粒径分布均一,形貌良好,且能够对黄芩素进行有效包封,载药量达23.9%。此外,体外药物释放试验结果表明:Baicalein@ZIF-8在微酸性环境中(pH 5.0)比在正常的生理条件下(pH 7.4)药物释放速度更快,在肿瘤治疗方面具有潜在的应用价值。

Baicalein belongs to the class of flavonoids and has antitumor activity. In this study,an insitu encapsulation strategy is designed by loading the baicalein on the zeolitic imidazolate framework-8(ZIF-8)at room temperature to synthetize the Baicalein@ZIF-8 nanomaterials,and the structural characterization is demonstrated. The results show that the synthesized nanoparticles have uniform particle size distribution,good morphology and effective encapsulation of baicalein,and the drug loading amount is determined to be 23.9%. In addition,the results of in vitro drug release assay demonstrate that the drug release rate in a slightly acidic environment(pH 5.0)is faster than that under physiological conditions(pH 7.4),suggesting the synthesized nanoparticles Baicalein@ZIF-8 have potential application in tumor therapy.