异甘草酸镁对经导管动脉栓塞化疗术后原发性肝癌患者肝功能和细胞免疫的影响

Effect of magnesium isoglycyrrhizinate on liver function and cellular immunity in patients with primary hepatic carcinoma undergoing transcatheter arterial chemoembolization

目的 探讨异甘草酸镁对经导管动脉栓塞化疗(TACE)术后原发性肝癌(PHC)患者肝功能和细胞免疫的影响。方法 将82例行TACE治疗的PHC患者按照治疗方法不同分为对照组和观察组,每组41例。对照组患者给予还原型谷胱甘肽治疗,观察组患者给予异甘草酸镁治疗。观察并比较两组患者的肝功能指标[总胆红素(TBIL)、丙氨酸转氨酶(ALT)及天冬氨酸转氨酶(AST)]、细胞免疫因子(CD3~+、CD4~+、CD8~+)、炎症因子[肿瘤坏死因子-α(TNF-α)、核因子κB(NF-κB)与白细胞介素-6(IL-6)]水平及不良反应。结果 治疗2周后,两组患者TBIL、ALT、AST水平均高于本组治疗前,但观察组患者TBIL、ALT、AST水平均低于对照组,差异均有统计学意义(P﹤0.05)。治疗2周后,两组患者CD3~+、CD4~+水平均高于本组治疗前,CD8~+水平均低于本组治疗前,且观察组患者CD3~+、CD4~+水平均高于对照组,CD8~+水平低于对照组,差异均有统计学意义(P﹤0.05)。治疗2周后,两组患者TNF-α、NF-κB及IL-6水平均低于本组治疗前,且观察组患者TNF-α、IL-6及NF-κB水平均低于对照组,差异均有统计学意义(P﹤0.05)。观察组患者不良反应总发生率低于对照组患者,差异有统计学意义(P﹤0.05)。结论 异甘草酸镁能有效减轻肝组织炎症,增强患者免疫功能,保护行TACE治疗的PHC患者的肝功能,减轻肝损伤程度。

Objective To explore the effect of magnesium isoglycyrrhizinate on liver function and cellular immunity in patients with primary hepatic carcinoma(PHC) undergoing transcatheter arterial chemoembolization(TACE).Method A total of 82 PHC patients treated with TACE were divided into control group(n=41,received reduced glutathione) and observation group(n=41,received magnesium isoglycyrrhizinate) according to different treatment methods.The liver function indicators [total bilirubin(TBIL),alanine aminotransferase(ALT),aspartate aminotransferase(AST)],cellular immune factors(CD3^(+),CD4^(+),CD8^(+)) and inflammatory factors [tumor necrosis factor-α(TNF-α),nuclear factor-κB(NF-κB),interleukin-6(IL-6)] and adverse reactions were compared between the two groups.Result After 2 weeks of treatment,the levels of TBIL,ALT and AST in the two groups were higher than those before treatment,with lower levels in observation group than those in control group(P<0.05);the levels of CD3^(+) and CD4^(+) in the two groups were higher,and CD8^(+) lower than those before treatment,with higher CD3^(+) and CD4^(+) and lower CD8^(+) in the observation group than those in control group(P<0.05);the levels of TNF-α,IL-6 and NF-κB were lower than those before treatment,with lower levels in observation group than those in control group(P<0.05).The total incidence rate of adverse reactions in observation group was lower than that in control group(P<0.05).Conclusion Magnesium isoglycyrrhizinate can effectively relieve the liver inflammation,enhance the immune function,protect the liver function and reduce the degree of liver damage of PHC patients treated by TACE.