摘要
IgA肾病(IgA nephropathy,IgAN)是常见的原发性肾小球疾病。血清中IgA的异常增多被认为是IgAN发生发展的启动阶段,而发生在B细胞中的IgA抗体类别转换过程失调导致了IgA的过度产生。该文从黏膜免疫、T细胞、细胞因子及信号通路等方面,对IgA抗体类别转换在IgAN发病机制中的作用,以及可能存在的相关治疗靶点作一综述,以期为IgAN的防治提供新思路。
IgA nephropathy(IgAN)is a common primary glomerular disease.The abnormal increase of IgA molecules in serum can be regarded as the initiation stage of IgAN development,and the abnormal IgA antibody class switch process in B cells leads to the overproduction of IgA.In order to provide new ideas for the prevention and treatment of IgAN,this paper reviews the role of IgA antibody class switch in the pathogenesis of IgAN from the aspects of mucosal immunity,T cells,cytokines and signaling pathways,as well as possible therapeutic targets.
作者
谷睿(综述)
王琴
张建江(审校)
Gu Rui;Wang Qin;Zhang Jianjiang(Department of Pediatrics,the First Affiliated Hospital of Zhengzhou University,Clinical Center of Pediatric Nephrology of Henan Province,Zhengzhou 450000,China)
出处
《国际儿科学杂志》
2022年第7期438-442,共5页
International Journal of Pediatrics
基金
河南省高等学校重点科研项目计划(21A320070)。
