大豆粉尿代谢产物雌马酚、双氢化大豆黄素、邻脱甲基安哥拉紫檀素与围绝经期症状的相关性分析

Study on the effectiveness of soybean powder urine metabolites estrol,dihydrodaidzein,o-demethylated Angolan red sandalwood and perimenopausal symptoms

目的评价大豆粉改善围绝经期症状的疗效。方法随机选取2016年7月至2019年12月期间,97例围绝经期患者为研究对象,完成患者围绝经期症状评分,征得患者同意并获医院伦理审批后,让其日服用50 g大豆粉,持续90 d后,重新完成评分,比较患者服用大豆粉前后出现围绝经期症状阳性率和评分的差异。测定患者尿代谢产物雌马酚、双氢化大豆黄素、邻脱甲基安哥拉紫檀素的含量,分析代谢产物与围绝经期症状的相关性。结果(1)患者服用大豆粉后出现围绝经期症状的阳性率低于服用大豆粉前,差异有统计学意义(χ^(2)=53.41,P<0.001)。(2)患者服用大豆粉后出现围绝经期症状的综合评分低于服用大豆粉前,差异有统计学意义(H=-8.52,P<0.001)。(3)尿代谢物雌马酚剂量与围绝经期症状加权总分、失眠均呈负相关(r=-0.23,P=0.02)。双氢化大豆黄素与心悸呈负相关(r=-0.27,P=0.007)。邻脱甲基安哥拉紫檀素与潮热出汗、情绪波动、心悸均呈负相关(r_(1)=-0.22,P1=0.03;r_(2)=-0.21,P_(2)=0.04;r_(3)=-0.21,P_(3)=0.04)。结论服用大豆粉有利于降低患者围绝经期症状的发生和严重程度。雌马酚含量与患者围绝经期的症状及睡眠质量相关。双氢化大豆黄素含量与患者的心悸相关。邻脱甲基安哥拉紫檀素含量与患者潮热出汗、情绪波动及心悸的症状相关。

Objective To evaluate the efficacy of soybean powder in improving perimenopausal symptoms.Methods 97 perimenopausal patients were randomly selected from July 2016 to December 2019 to complete the perimenopausal symptom score.With the consent of the patients and the ethical approval of the hospital,they were allowed to take 50 grams of soybean powder a day for 90 days,and then complete the score again.The positive rate and score of perimenopausal symptoms before and after taking soybean powder were compared.The contents of urine metabolites estrol,dihydrodaidzein and o-demethylated Angolan red sandalwood were measured,and the correlation between metabolites and perimenopausal symptoms was analyzed.Result(1)the positive rate of perimenopausal symptoms after taking soybean powder was lower than that before taking soybean powder,and the difference was statistically significant(χ^(2)=53.41,P<0.001).(2)The comprehensive score of perimenopausal symptoms after taking soybean powder was lower than that before taking soybean powder,and the difference was statistically significant(H=-8.52,P<0.001).(3)The dose of urinary metabolite estrol was negatively correlated with perimenopausal symptom weighted total score and insomnia(r=-0.23,P=0.02).Dihydrodaidzein was negatively correlated with palpitation(r=-0.27,P=0.007).O-demethyl angola nobilin was negatively correlated with hot flashes,sweating,mood swings,and palpitations(r_(1)=-0.22,P_(1)=0.03;r_(2)=-0.21,P_(2)=0.04;r_(3)=-0.21,P_(3)=0.04).Conclusion Taking soybean powder is beneficial to reduce the occurrence and severity of perimenopausal symptoms.The content of estrol is related to perimenopausal symptoms and sleep quality.Dihydrodaidzein content is related to palpitation in patients.The content of o-demethylated Angolan rosewood is related to the symptoms of hot flashes,sweating,mood swings and palpitations.