纳米技术在疼痛治疗中的应用进展

Applications of Nanotechnology for Pain Management

疼痛是最常见的临床症状之一,与疾病的发生和进展密切相关,且在很大程度上影响患者的生存质量。目前主要的疼痛治疗方案依赖于阿片类药物,但由于该类药物具有一定的副作用及成瘾性,需不断开拓新的治疗方法。纳米技术的应用能够进行针对性的治疗,而不产生或较少产生相关的副作用。本文将阐述临床疼痛治疗的现状、疼痛治疗的新靶点以及纳米技术在疼痛治疗方面的应用进展,重点介绍基于纳米颗粒的药物递送方法以及借助纳米材料清除代谢因子从而调节疼痛信号的技术。

Pain is one of the most common clinical symptoms,which is closely related to the occurrence and progression of the disease,and affects the quality of life of patients to a great extent.Opioids are currently the mainstay of pain treatment,yet new treatments are stillurgently required due to their lethal side effects and addictive nature.The introduction of nanotechnology has great potential to address this dilemma by enabling targeted treatments with few or no associated side effects.In this review,we will review the current status of clinical pain treatment,new targets for pain treatment,and the progress of applicationof nanotechnology in pain treatment management,with emphasis on nanoparticle based drug delivery methods and the modulation of pain signals through the removal of metabolic factors by nanomaterials.