1990-2019年中国儿童青少年智力残疾疾病负担变化趋势研究

Trends of the disease burden of intellectual disability among children and adolescents from 1990 to 2019 in China

目的分析中国0~19岁儿童青少年智力残疾现状及其1990-2019年疾病负担的长期变化趋势。方法数据来源于全球疾病负担研究。分性别、年龄及残疾严重程度比较2019年全球与中国儿童青少年智力残疾患病率及伤残损失健康生命年(YLDs)分布特征。使用Joinpoint回归模型分析1990-2019年中国儿童青少年智力残疾患病率及YLDs的长期变化趋势。结果2019年中国儿童青少年智力残疾患病率和YLDs分别为1522.65/10万(95%UI:1228.62/10万~1817.55/10万)和109.81人年/10万(95%UI:72.15人年/10万~158.09人年/10万),明显低于全球平均水平,而重度智力残疾患病率和YLDs略高于全球平均水平。1990-2019年中国儿童青少年智力残疾患病率和YLDs的平均年度变化百分比分别为-0.23%(95%CI:-0.26%~-0.21%,P<0.001)和0.74%(95%CI:0.66%~0.81%,P<0.001)。重度智力残疾患病率及YLDs在这30年间呈现持续上升趋势。结论2019年中国儿童青少年智力残疾疾病负担低于全球平均水平,重度智力残疾疾病负担高于全球平均水平。1990-2019年中国儿童青少年智力残疾患病率整体呈现下降趋势,YLDs呈现上升趋势。

Objective This study aims to analyze the disease burden of intellectual disability among Chinese children and adolescents aged 0-19 years in 2019 and its trends from 1990 to 2019.Methods Data were gathered from the Global Burden of Disease study.The prevalence and years lived with disability(YLDs)of intellectual disability among Chinese children and adolescents were compared with the global average by gender,age group,and severity of disability in 2019.Joinpoint regression model was used to analyze the trends in the prevalence and YLDs of intellectual disability among Chinese children and adolescents from 1990 to 2019.Results The prevalence and YLDs of intellectual disability among Chinese children and adolescents in 2019 were 1522.65 per 100000(95%UI:1228.62 per 100000-1817.55 per 100000)and 109.81 per 100000(95%UI:72.15 per 100000-158.09 per 100000),respectively,which were lower than the global average.The prevalence and YLDs of severe intellectual disability in China were slightly higher than the global average.The average annual percent changes in the prevalence and YLDs of intellectual disability among Chinese children and adolescents were-0.23%(95%CI:-0.26%--0.21%,P<0.001)and 0.74%(95%CI:0.66%-0.81%,P<0.001)from 1990 to 2019,respectively.The prevalence and YLDs of severe intellectual disability showed continuously increasing trends over the past 30 years.Conclusions The disease burden of intellectual disability among Chinese children and adolescents was lower than the global average in 2019,but severe intellectual disability was higher than the global average.The prevalence of intellectual disability among Chinese children and adolescents showed an overall decrease,while YLDs showed an increasing trend from 1990 to 2019.