PET分子探针在类风湿关节炎中的研究进展

Research progress of PET molecular probes in rheumatoid arthritis

类风湿关节炎(RA)是一种病因未明的、以滑膜炎为主要特征的慢性自身免疫性疾病,多累及手、足部小关节,呈对称性、侵袭性关节炎改变,最终导致关节畸形甚至功能丧失。不同于传统的影像学检查方法,PET提供了一种在细胞水平上的显像方法,是一种潜在的、高度灵敏的滑膜炎评估方法。笔者就PET分子探针在RA中的临床应用及研究进展进行综述,旨在为RA的诊断提供思路。

Rheumatoid arthritis(RA)is a chronic autoimmune disease characterized by synovitis with unknown etiology,which often involves the facet joints of hands and feet,showing symmetrical and invasive arthritis changes,resulting in joint deformities and even loss of function.Different from traditional imaging methods,PET provides an imaging method at the cellular level and is a potential and highly sensitive method for the evaluation of synovitis.In this paper,clinical application and research progress of PET molecular probes in RA were reviewed in order to provide ideas for the diagnosis of RA.