Jumonji组蛋白去甲基化酶调控拟南芥的下胚轴伸长

Jumonji histone demethylases regulate hypocotyl elongation in Arabidopsis thaliana

光在植物各种器官的发育中起着重要作用。尽管有研究表明组蛋白去甲基化影响植物的光形态建成,但其表观遗传学机制尚不完全清楚。本文证明了组蛋白去甲基化酶Jumonji domain-containing protein30 (JMJ30)及其亚基因家族成员JMJ32、relative of early flowering 6 (REF6)和early flowering 6 (ELF6)对红光条件下植株下胚轴的伸长至关重要。在红光条件下, JMJ30的表达被抑制且JMJ30移去phytochrome interacting factor 7 (PIF7)启动子区域附近组蛋白的H3K27me3从而激活PIF7表达。此外,过表达PIF7可以补偿jmj突变体下胚轴缩短的表型。综上, JMJs-PIF7在调节植物适应光信号过程中具有重要功能。

Light plays an important role in the development of various plant organs. Although studies suggest that histone demethylation influences plant photomorphogenesis, these epigenetic mechanisms are not fully understood. Here, we show that histone demethylases Jumonji domain-containing protein 30(JMJ30) and its subfamily members JMJ32, relative of early flowering 6(REF6) and early flowering 6(ELF6) are essential for red light regulation of hypocotyl elongation. Under red light condition, JMJ30 expression is repressed and JMJ30 protein removes H3 lysine 27 trimethylation(H3K27me3) from the promoter region of phytochrome interacting factor 7(PIF7) and then activate PIF7 expression. Moreover, overexpression of PIF7 in jmj mutants can rescue the short hypocotyl phenotype. Our findings highlight the importance of the JMJs-PIF7 in mediating adaptation of plants to light signals.