从“肾藏精”理论探讨外泌体与糖尿病肾病的相关性

Discussion on Relationship Between Exosomes and Diabetic Nephropathy from Theory of "Kidney Storing Essence"

糖尿病肾病是临床上常见的糖尿病慢性并发症,易进展至终末期肾病。外泌体是一种直径为30~120 nm的囊泡,内含大量的核酸和蛋白质。造血细胞、上皮细胞、神经元细胞等都能释放外泌体。外泌体参与了糖尿病肾病的发生发展,并加快了疾病的发展变化。糖尿病肾病主要病位在肾,肾脏虚损导致肾失封藏,肾不固精导致精微外泄。补肾益精法可作为糖尿病肾病的基本治则,可有效缓解糖尿病肾病的症状,减缓人体精微的流失,保护肾功能。

Diabetic nephropathy(DN) is a common clinical chronic complication of diabetes, which is easy to progress to end stage renal disease(ESRD).Exosomes are vesicles with a diameter of 30-120 nm that contain a large number of nucleic acids and proteins.Hematopoietic cells, epithelial cells, neuronal cells, etc.all can release exosomes.Exosomes are involved in the occurrence and development of DN and accelerate the development and changes of the disease.DN is mainly located in the Kidney.Kidney deficiency leads to the loss of the control of the Kidney, and the failure of the Kidney to consolidate the Essence leads to the leakage of the essence.The method of tonifying Kidney and nourishing Essence can be used as the basic treatment principle of DN,which can effectively relieve the DN symptoms, slow down the loss of body Essence, and protect Kidney function.