网络游戏障碍人群大脑功能网络rich club结构的改变

The Alteration of Rich Club in Brain Functional Network in Internet Gaming Disorder

网络游戏障碍(internet gaming disorder,IGD)极大的影响了青少年的学习与生活.IGD于2013年被纳入《精神障碍诊断与统计手册》第5版(DSM-5),但其神经机制还不清楚.本研究通过静息态功能磁共振成像研究30例IGD被试以及年龄、性别与之匹配的30例健康对照,分析他们大脑功能网络的rich club结构的差异.结果表明,IGD组和对照组均存在rich club结构,rich club脑区主要包含默认模式、执行控制、突显、感觉运动、听觉与视觉网络中的脑区;同时IGD组的rich club连接增加;此外,IGD组的右侧眶部额下回的度显著高于健康对照组.这些发现表明了IGD人群大脑功能网络的rich club结构发生了改变.

Internet gaming disorder(IGD)has a great negative impact on teenagers’study and life.It has been included in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders in 2013.However,the neural mechanism of its effect is yet to be unveiled.In this study,we used resting-state functional magnetic resonance imaging(resting-state fMRI)to explore the differences of rich club structures in the functional brain networks of 30 IGD subjects and 30 age/sex-matched healthy controls.The rich club was found in both IGD subjects and healthy controls,involving important brain regions in default mode,executive control,salience,sensorimotor,auditory and visual networks.IGD subjects had significantly higher rich club connection and higher degree in the right pars orbitalis of inferior frontal gyrus than healthy controls.These findings might suggest that IGD might be more correlated with damage to the rich club connection.