PD-1单抗治疗后发生单侧眼肌麻痹1例报告

Ocular immune-related adverse event associated with PD-1:a case report

接受免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)治疗的患者常发生免疫相关不良事件(immune-related adverse events,irAEs),但免疫相关眼不良事件(ocular immune-related adverse events,oAEs)罕见。本文报告1例因淋巴瘤接受PD-1单抗治疗后发生孤立性眼肌麻痹病例。该例患者在接受帕博丽珠单抗(pembrolizumab)治疗6个月后出现复视,左眼外展受限,全身MRI提示同侧眶周肌肉增粗、未累及其他肌肉。患者停用帕博丽珠单抗,并接受中剂量泼尼松治疗后,眼部症状很快恢复正常。现将过程报告如下。