加贝酯联合生长抑素对高脂血症性急性胰腺炎患者的治疗效果分析

Analysis of the Therapeutic Effect of Gabexate Combined with Somatostatin in Patients with Hyperlipidemia Acute Pancreatitis

目的:探讨加贝酯联合生长抑素对高脂血症性急性胰腺炎患者的治疗效果。方法:选取于重庆市巴南区第二人民医院2017年5月—2020年5月接受治疗的60例高脂血症性急性胰腺炎患者作为研究对象,以随机数表法分为单一组30例和联合组30例。单一组患者给予生长抑素治疗,联合组患者在单一组的基础上给予加贝酯治疗,两组患者均连续治疗14 d。比较两组患者临床症状改善时间,治疗前、治疗14 d后的炎症反应及血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平。结果:联合组患者血淀粉酶恢复时间长于单一组,而腹痛缓解时间、肠功能恢复时间、住院天数均短于单一组,差异有统计学意义(t=4.841、12.735、8.079、4.396,P<0.05)。与治疗前相比,治疗14 d后两组患者外周血白细胞计数(WBC)及血清C反应蛋白(CRP)、TC、TG、LDL-C水平均降低,且联合组低于单一组,差异有统计学意义(t=10.151、67.922、7.882、18.389、17.620,P<0.05)。结论:加贝酯联合生长抑素可明显抑制高脂血症性急性胰腺炎患者的炎症反应,缓解腹痛情况,加速肠道功能恢复,同时降低血脂水平。

Objective: To investigate the therapeutic effect of gabexate combined with somatostatin on patients with hyperlipidemia acute pancreatitis. Methods: A total of 60 patients with hyperlipidemia acute pancreatitis who received treatment in the hospital from May 2017 to May 2020 were selected as the research subjects, and they were divided into the single group 30 cases and the combined group 30 cases by random number table methods. The patients in the single group were treated with somatostatin, and the patients in the combination group were treated with gabexate on the basis of the single group. Both groups were treated for 14 d.The improvement time of clinical symptoms, inflammatory response and the levels of serum total cholesterol(TC), triglyceride(TG) and low-density lipoprotein cholesterol(LDL-C) before treatment and 14 d after treatment were compared between the two groups.Results: The recovery time of blood amylase in the combined group was longer than that in the single group, while the abdominal pain relief time, bowel function recovery time, and hospitalization days were shorter than those in the single group, and the differences were statistically significant(t=4.841, 12.735 8.079, 4.396, P<0.05). Compared with before treatment, after 14 d of treatment, the levels of peripheral blood white blood cell count(WBC), serum C-reactive protein(CRP), TC, TG, and LDL-C in the two groups decreased, and the combined group was lower than the single group, and the differences were statistical significance(t=10.151, 67.922, 7.882, 18.389, 17.620, P<0.05). Conclusion: Gabexate combined with somatostatin could significantly inhibit the inflammatory response in patients with hyperlipidemia acute pancreatitis, relieve abdominal pain, rapidly recover intestinal function,and reduced blood lipid levels at the same time.