牡丹江市林区人群血清中蜱传脑炎病毒抗体水平调查及加强免疫效果研究

Investigation on Antibody Level of Tick Borne Encephalitis and Efficacy on Booster of Vaccine in Forest Area of Mudanjiang

目的:调查黑龙江省牡丹江市林区人群蜱传脑炎病毒抗体水平,并对有免疫史人群进行加强免疫效果评价。方法:调查350名0~60岁林区生活人群,于2019年3月采集首份血液样本,选择初次采血后2个月内接种森林脑炎疫苗的人群采集疫共免后血清,共成功采集360份。使用酶联免疫吸附试验(ELISA)方法,检测血清中蜱传脑炎病毒IgG抗体。结果:调查的350人中56.3%有既往免疫史,主要集中在成年人。40.0%的调查对象抗体呈阳性,GMC为290.2 U/mL。本次加强免疫后抗体阳转率77.8%。结论:牡丹江林区人群抗体阳性率较高,蜱传脑炎流行风险可控。

Objective: To investigate tick-borne encephalitis antibody levels in forest area of Mudanjiang so as to provide reference for disease prevention and control. Methods: A survey of 350 people aged 0-60 living in forest areas was conducted. The first blood samples were collected in March 2019. A total of 360results were collected from people who were vaccinated wifh forest brain vaccine within 2 months after the initial blood collection. IgG antibodies to tick-borne encephalitis virus in serum were detected by enzyme-linked immunosorbent assay(ELISA). Results: Of the 350 people surveyed, 56.3% had a history of previous immunization, mainly in adults. 40.0% of the survey subjects were positive for antibodies, and the GMC was 290.2 U/mL. The antibody positive conversion rate after this booster immunization was 77.8%. Conclusion: The positive rate of antibodies in the population of Mudanjiang forest area is relatively high, and the epidemic risk of tick-borne encephalitis is controllable.