急性冠脉综合征患者血浆和肽素、正五聚蛋白3、血小板衍生生长因子-BB与冠状动脉狭窄程度的相关性

Correlation of Plasma Copeptin,N-pentagerin-3,Platelet-derived Growth Factor-BB with the Degree of Coronary Artery Stenosis in Patients with Acute Coronary Syndrome

目的:探讨急性冠脉综合征(ACS)患者血浆和肽素(copeptin)、正五聚蛋白3 (PTX3)、血小板衍生生长因子-BB (PDGF-BB)与冠状动脉狭窄程度的关系。方法:选取揭阳市中医院ACS患者126例,根据冠状动脉狭窄程度分Ⅲ级组、Ⅳ级组。对比两组血浆copeptin、PTX3、PDGF-BB水平,分析上述生化指标与冠状动脉狭窄程度间关系。结果:两组患者心功能、LDL-C、UA、CK、CKMB对比,差异有统计学意义(t=2.118、2.492、4.150、5.103,P<0.05);Ⅳ级组血浆copeptin、PTX3、PDGF-BB水平高于Ⅲ级组,差异有统计学意义(t=3.414、4.629、6.791,P<0.05)。多因素logistic回归方程校正心功能分级、CK、CKMB后,copeptin、PTX3、PDGF-BB仍与冠状动脉狭窄程度相关。结论:ACS患者血浆copeptin、PTX3、PDGF-BB水平随冠状动脉狭窄程度加重而升高,其水平变化与冠状动脉狭窄程度呈独立显著相关。

Objective: To investigate the relationship between plasma copeptin, pentraxin 3(PTX3), platelet-derived growth factor-BB(PDGF-BB) and the degree of coronary stenosis in patients with acute coronary syndrome(ACS). Methods: A total of 126patients with ACS in hospital were selected and divided into grade III group and grade IV group according to the degree of coronary stenosis. The plasma levels of copeptin, PTX3 and PDGF-BB were compared between the two groups, and the relationship between the above biochemical indicators and the degree of coronary stenosis was analyzed. Results: There were significant differences in cardiac function, LDL-C, UA, CK, and CKMB between the two groups(t=2.118, 2.492, 4.150, 5.103, P<0.05). The plasma levels of copeptin, PTX3 and PDGF-BB in grade Ⅳ group were higher than those in grade Ⅲ group, and the difference was statistically significant(t=3.414, 4.629, 6.791, P<0.05). After the multivariate logistic regression equation was used to correct cardiac function classification, CK, and CKMB, copeptin, PTX3, and PDGF-BB were still related to the degree of coronary stenosis. Conclusion: Plasma copeptin, PTX3 and PDGF-BB levels in ACS patients increased with the severity of coronary stenosis, and their levels were independently and significantly correlated with the degree of coronary stenosis.