艾地苯醌治疗非痴呆型脑小血管病认知障碍的临床研究

Clinical Study of Idebenone in the Treatment of Cognitive Impairment in Non-dementia Cerebral Small Vessel Disease

目的探讨非痴呆型脑小血管病认知障碍患者使用艾地苯醌进行治疗的临床效果。方法选择本院2019年6月至2021年6月期间收治的118例脑小血管病存在非痴呆型认知障碍的患者,随机分成A组58例和B组60例,B组患者给予常规控制危险因素,A组在此基础上给予艾地苯醌治疗,对比两种治疗方案的疗效。结果治疗前,两组MoCA、MMSE评分相比,差异无统计学意义(P>0.05);治疗后,两组MoCA、MMSE评分对比,差异有统计学意义(P<0.05)。治疗后,MoCA、MMSE评分总有效率A组均高于B组,差异有统计学意义(P<0.05)。其中,满足MoCA评分减分率≥12%同时又满足MMSE评分减分率≥12%的患者,A组有38例,B组有7例,A组明显多于B组。两组患者的不良反应发生率对比,差异无统计学意义(P>0.05)。结论非痴呆型脑小血管病认知障碍患者应用艾地苯醌治疗的临床效果显著,可有效改善患者的认知障碍,提高患者生活质量,且治疗安全性较高。

Objective To explore the clinical effect of idebenone in the treatment of cognitive impairment patients with non-demented cerebral small vessel disease.Methods A total of 118 patients with cerebral small vessel disease and non-dementia cognitive impairment who were admitted to our hospital from June 2019 to June 2021 were selected and randomly divided into group A(n=58)and group B(n=60),patients in group B were given routine control of risk factors,and group A was given idebenone treatment on this basis,and the efficacy of the two treatment regimens was compared.Results Before treatment,there was no significant difference in MoCA score and MMSE score between the two groups(P>0.05);after treatment,there was a statistically significant difference in MoCA score and MMSE score between the two groups(P<0.05).After treatment,the total effective rates of MoCA and MMSE scores in group A were higher than those in group B,and the difference was statistically significant(P<0.05).Among them,there were 38 patients in group A and 7 patients in group B who met the MoCA score reduction rate of≥12%and the MMSE score reduction rate of≥12%.Group A was significantly more than group B.There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The clinical effect of idebenone in the treatment of cognitive impairment patients with non-demented cerebral small vessel disease is significant,which can effectively improve the cognitive impairment of patients,improve the quality of life of patients,and the treatment safety is high.