苦参异戊烯基黄酮的化学成分及生物活性研究进展

Research progress on chemistry and bioactivity of isopentenyl flavonoids from Sophora flavescens

异戊烯基黄酮类化合物是苦参中的一类特征性成分,具有抗肿瘤、抗菌、抗炎、抗氧化等生物活性。本文对苦参异戊烯基黄酮的结构类型,毒理、药理作用进行简要综述,并提出其药代动力学、药效学、毒理学、作用靶标、分子机制、构效关系等方面仍值得深入研究。通过对苦参异戊烯基黄酮功能特性系统深入地挖掘并将其应用到创新药物的开发中,这对于进一步提高苦参异戊烯基黄酮产品附加值、拓展其应用领域具有重要意义。

Isopentenyl flavonoids are a class of characteristic components in Sophora flavescens Ait.(S.flavescens).They have biological activities such as anti-tumor,anti-bacteria,anti-inflammol/Lation and anti-oxidation.In this paper,the structural types,toxicology and pharmacological effects of isopentenyl flavonoids from S.flavescens were briefly reviewed.Furthermore,the worth of further study on pharmacokinetics,pharmacodynamics,toxicology,action targets,molecular mechanisms and structure-function relationships of isopentenyl flavonoids were proposed.The deep exploration on functional characterastics of isopentenyl flavonoids of S.flavescens and their application on development of innovative drugs are of great significance to further improve the added value of isopentenyl flavonoids and expand their application fields.