关于体力活动提升中老年人免疫力综述研究

A Review on the Improvement of Immunity of Middle-aged and Elderly People with Physical Activity

采用文献资料法,搜索了PubMed、ScienceDirect、WebofScience、SportsDiscus、SpringerLink等数据库,着力综述体力活动对于提升中老年人免疫力的各类研究成果,运用相应的统计学方法,将所收集到的本专题各类研究文献加以综述。研究发现:体力活动在影响中老年人的外周白细胞(SMD=-0.15,95%CI:-0.51~0.22)、中性粒细胞(SMD=-0.08,95%CI:-0.57~0.42)和NK细胞(SMD=0.41,95%CI:-1.53~2.36)无明显影响;使淋巴细胞含量明显提高(SMD=0.14,95%CI:0.02~0.31)。体力活动能够提高中老年人CD4+、CD4+/CD8+的比值,分别提高了0.22、0.06个标准差,对CD8+T细胞没有明显变化(P>0.05);而对TNF-a和IL-6均无明显的影响。在此基础上,本研究认为,中老年人参与体力活动能使其外周淋巴细胞、CD4+、CD4+/CD8+的比值明显升高;白细胞、中性粒细胞和IL-6含量则有降低趋势;NK细胞、CD8+细胞和TNF-a的含量有升高趋势。

Using the literature method,we searched databases such as PubMed,Science Direct,Web of Science,Sports Discus,Springer Link,etc.,and focused on reviewing various research results related to the improvement of immunity of the middle-aged and the elderly by physical activity.Using appropriate statistical methods,a variety of research literatures collected on this topic were reviewed.The study found that physical activity affects peripheral leukocytes(SMD=-0.15,95%CI:-0.51~0.22),neutrophils(SMD=-0.08,95%CI:-0.57~0.42)and NK in middle-aged and elderly people cells(SMD=0.41,95%CI:-1.53-2.36)had no significant effect;the content of lymphocytes was significantly increased(SMD=0.14,95%CI:0.02~0.31).Physical activity can increase the ratio of CD4+and CD4+/CD8+in middle-aged and elderly people by 0.22 and 0.06 standard deviations,respectively,with no significant change in CD8+T cells(P>0.05);but no significant change in TNF-a and IL-6 obvious impact.On this basis,this study believes that physical activity in middle-aged and elderly people can significantly increase the ratio of peripheral lymphocytes,CD4+,CD4+/CD8+;white blood cells,neutrophils,and IL-6 levels tend to decrease;NK The contents of cells,CD8+cells and TNF-a tended to increase.