体外受精-胚胎移植患者生活质量现状及影响因素

Analysis of fertility quality of in vitro fertilization and embryo transfer patients

目的调查初次与再次体外受精-胚胎移植患者生育生活质量及生育相关压力现状,分析其差异性及影响因素。方法选择2020年10—12月在广东省深圳市某三甲医院生殖医学科接受辅助生殖技术的不孕症患者为调查对象,其中再次治疗患者44例,初次治疗患者151例。采用患者基本情况调查表、中文版生育生活质量量表(FertiQoL)、生育压力量表(FPI)进行横断面调查,比较两组患者生育生活质量及生育压力现状差异。结果两组评分结果比较显示,再次治疗患者的生育生活质量55.2±9.3分,低于初次治疗患者60.8±8.0分,差异有统计学意义(P<0.05),两组在情感领域、精神躯体领域、夫妻关系、社会关系、治疗耐受性维度的评分差异均有统计学意义(P<0.05)。再次治疗患者生育压力168.4±16.7分,高于初次治疗患者155.0±20.6分,差异有统计学意义(P<0.05),两组在社会压力、性压力、夫妻关系、无生育子女压力维度的评分差异有统计学意义(P<0.05)。多元逐步线性回归分析结果显示,再次治疗、文化程度较高、居住在农村地区是影响生育生活质量的危险因素(P<0.05)。结论初次及再次接受IVF-ET治疗患者群体存在一定程度的生育压力,生育生活质量均受到影响,其中再次IVF-ET治疗患者的生育生活质量影响更为明显,所承受的生育压力也更大。医务工作者需重视两者之间的差异进行阶段性干预。

Objective To investigate the quality of life and fertility related stress in patients with in vitro fertilization and embryo transfer,to analyze the diff erences and infl uencing factors.Methods Infertility patients who received assisted reproductive technology in the Department of Reproductive Medicine of a Class III Grade A hospital in Shenzhen of Guangdong Province from October to December 2020 were selected as the study objects,including 44 patients who received retreatment and 151 patients who received initial treatment.The patients'basic information questionnaire,Chinese version of Fertility Quality of Life Scale(FertiQoL)and Fertility Problem Inventory(FPI)were used to operate the cross-sectional investigation,the diff erences of fertility quality of life and fertility pressure between the two groups were compared.Results The comparison of the scores between the two groups showed that the quality of reproductive life of the patients with the second treatment was 55.2±9.3 points,which was lower than the patients who received initial treatment,which was 60.8±8.0 points,and the diff erence was statistically signifi cant(P<0.05).There were signifi cant diff erences in the scores of emotional domain,psychosomatic domain,marital relationship,social relationship and treatment tolerance between the two groups(P<0.05).The score of fertility pressure of the patients who received retreatment was 168.4±16.7 points,which was higher than the patients who received initial treatment,which was 155.0±20.6 points,the difference was statistically significant(P<0.05).The scores of social pressure,sexual pressure,marital relationship and childless pressure between the two groups were statistically signifi cant(P<0.05).The results of multiple stepwise linear regression analysis showed that retreatment,higher education level and living in rural areas were the risk factors affecting the quality of life of childbirth(P<0.05).Conclusions There was a certain degree of fertility pressure in the patients receiving IVF-ET treatment for the fi rst time and again,and the quality of reproductive life was aff ected.Among them,the patients receiving IVF-ET treatment for the second time had a more obvious impact on the quality of reproductive life and bear greater fertility pressure.Medical staff s should pay attention to the diff erence between them and carry out staged intervention.